Testing Data
VX-745, inhibitor
VX-745
Synonyms
VX-745; inhibitor
Solubility
DMSO >=63 mg/mL - Water <1 mg/mL - Ethanol <1 mg/mL
Formula
C19H9Cl2F2N3OS
CAS Number
209410-46-8
Preparation and Storage
Stable for; 2 years at -20 degree C Powder
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
Testing Data
Testing Data
Related Product Information for VX-745, inhibitor
VX-745 is a lead anti-inflammatory candidate, p38 MAPK inhibitor (IC50=10 nM) for the treatment of Rheumatoid arthritis (RA). p38 MAPK is a specific enzyme that regulates the production of IL-1, IL-2, IL-6, TNFalpha, chemokines and nitric oxide (NO), as part of acute and chronic inflammatory responses. In vitro, VX-745 was selective for p38 MAPK compared to a large panel of kinases (IC50>=20uM). VX-745 selectively inhibited p38alpha MAPK (IC50=10 nM), p38beta MAPK (IC50 =220 nM) [368149], but not p38 gamma MAPK (IC50>=20 uM). In addition, cell data for VX-745 provided IC50 values of 56 and 52 nM for IL-1beta and TNFalpha, respectively, and VX-745 blocked IL-6 and IL-8 production induced by IL-1 and TNFalpha. In a human whole blood assay, IC50 values were 152 and 177 nM for IL-1beta and TNFalpha inhibition, respectively. [1]
Product Categories/Family for VX-745, inhibitor
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Product Notes
The VX-745 (Catalog #AAA8506468) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "VX-745, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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