Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Mouse Integrin Beta 3 Polyclonal Antibody | anti-ITGb3 antibody
Polyclonal Antibody to Integrin Beta 3 (ITGb3)
MHHHHHHSSG LVPRGSGMKE TAAAKFERQH MDSPDLGTDD DDKAMADIGS EF- DYPVDI YYLMDLSFSM KDDLSSIQTL GTKLASQMRK LTSNLRIGFG AFVDKPVSPY MYISPPQAIK NPCYNMKNAC LPMFGYKHVL TLTDQVSRFN EEVKKQSVSR NRDAPEGGFD AIMQATVCDE KIGWRNDASH LLVFTTDAKT HIALDGRLAG IVLPNDGHCH IGTDNHYSAS TTMDYPSLGL MTEKLSQKNI NLIFAVTENV VSLYQNYSEL IPGTTVGVLS DDSSNVLQLI VDAYGKI
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded liver tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded liver tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Spleen Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Spleen Tissue))
NCBI and Uniprot Product Information
Uniprot Description
ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11 E1|11 67.84 cM
Cellular Component: alpha9-beta1 integrin-ADAM8 complex; apical plasma membrane; cell junction; cell projection; cell surface; external side of plasma membrane; extracellular exosome; filopodium membrane; focal adhesion; integral component of membrane; integrin alpha9-beta1 complex; integrin alphav-beta3 complex; integrin complex; melanosome; membrane; microvillus membrane; nucleus; plasma membrane; receptor complex
Molecular Function: C-X3-C chemokine binding; cell adhesion molecule binding; enzyme binding; extracellular matrix binding; fibroblast growth factor binding; fibronectin binding; identical protein binding; insulin-like growth factor I binding; integrin binding; neuregulin binding; peptide binding; protease binding; protein binding; protein disulfide isomerase activity; receptor activity; vascular endothelial growth factor receptor 2 binding
Biological Process: activation of protein kinase activity; angiogenesis involved in wound healing; apolipoprotein A-I-mediated signaling pathway; cell adhesion; cell adhesion mediated by integrin; cell growth; cell migration; cell projection morphogenesis; cell-matrix adhesion; cell-substrate adhesion; cell-substrate junction assembly; cellular calcium ion homeostasis; entry of virus into host cell; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; negative chemotaxis; negative regulation of lipid storage; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor biosynthetic process; negative regulation of macrophage derived foam cell differentiation; platelet activation; platelet-derived growth factor receptor signaling pathway; positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway; positive regulation of angiogenesis; positive regulation of bone resorption; positive regulation of cell adhesion mediated by integrin; positive regulation of cell migration; positive regulation of cell-matrix adhesion; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast migration; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of glomerular mesangial cell proliferation; positive regulation of leukocyte migration; positive regulation of MAPK cascade; positive regulation of osteoblast proliferation; positive regulation of osteoclast differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of T cell migration; regulation of actin cytoskeleton organization; regulation of cell migration; regulation of G-protein coupled receptor protein signaling pathway; regulation of release of sequestered calcium ion into cytosol; smooth muscle cell migration
Research Articles on ITGb3
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Product Notes
The ITGb3 itgb3 (Catalog #AAA2026479) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Integrin Beta 3 (ITGb3) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Integrin Beta 3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.2-2ug/mL;1:250-2500 Immunohistochemistry: 5-20ug/mL;1:25-100 Immunocytochemistry: 5-20ug/mL;1:25-100 Optimal working dilutions must be determined by end user. . Researchers should empirically determine the suitability of the ITGb3 itgb3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and S-tag and its sequence is listed below. MHHHHHHSSG LVPRGSGMKE TAAAKFERQH MDSPDLGTDD DDKAMADIGS EF- DYPVDI YYLMDLSFSM KDDLSSIQTL GTKLASQMRK LTSNLRIGFG AFVDKPVSPY MYISPPQAIK NPCYNMKNAC LPMFGYKHVL TLTDQVSRFN EEVKKQSVSR NRDAPEGGFD AIMQATVCDE KIGWRNDASH LLVFTTDAKT HIALDGRLAG IVLPNDGHCH IGTDNHYSAS TTMDYPSLGL MTEKLSQKNI NLIFAVTENV VSLYQNYSEL IPGTTVGVLS DDSSNVLQLI VDAYGKI. It is sometimes possible for the material contained within the vial of "Integrin Beta 3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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