Western Blot (WB)
(Lanes:1: 30ug HeLa lysate, 2: 30ug HFF lysate, 3: 30ug U2OS lysatePrimary Antibody Dilution:1:1000Secondary Antibody:Anti-rabbit HRPSecondary Antibody Dilution:1:5000Gene Name:ING1Submitted by:Dr. Hyung Suk Oh, Knipe Lab, Harvard Medical School)
Rabbit ING1 Polyclonal Antibody | anti-ING1 antibody
ING1 antibody - C-terminal region
Western Blot (WB)
(Lanes:1: 30ug HeLa lysate, 2: 30ug HFF lysate, 3: 30ug U2OS lysatePrimary Antibody Dilution:1:1000Secondary Antibody:Anti-rabbit HRPSecondary Antibody Dilution:1:5000Gene Name:ING1Submitted by:Dr. Hyung Suk Oh, Knipe Lab, Harvard Medical School)
Western Blot (WB)
(Lanes:1: 30ug HeLa lysate, 2: 30ug HFF lysate, 3: 30ug U2OS lysatePrimary Antibody Dilution:1:1000Secondary Antibody:Anti-rabbit HRPSecondary Antibody Dilution:1:5000Gene Name:ING1Submitted by:Dr. Hyung Suk Oh, Knipe Lab, Harvard Medical School)
Western Blot (WB)
(WB Suggested Anti-ING1 Antibody Titration: 2.5ug/mlPositive Control: HepG2 cell lysateThere is BioGPS gene expression data showing that ING1 is expressed in HepG2)
Western Blot (WB)
(WB Suggested Anti-ING1 Antibody Titration: 2.5ug/mlPositive Control: HepG2 cell lysateThere is BioGPS gene expression data showing that ING1 is expressed in HepG2)
Target Description: ING1 is a tumor suppressor protein that can induce cell growth arrest and apoptosis. The protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of ING1 gene have been detected in various cancers.This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
ING1: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC); also known as squamous cell carcinoma of the head and neck. Belongs to the ING family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: nucleus
Molecular Function: protein binding; zinc ion binding; methylated histone residue binding
Biological Process: negative regulation of cell proliferation; protein import into nucleus; positive regulation of transcription, DNA-dependent; chromatin modification; negative regulation of cell growth; cell cycle
Disease: Squamous Cell Carcinoma, Head And Neck
Research Articles on ING1
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Product Notes
The ING1 ing1 (Catalog #AAA3209968) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ING1 antibody - C-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish and may cross-react with other species as described in the data sheet. AAA Biotech's ING1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the ING1 ing1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: EKKAKTSKKK KRSKAKAERE ASPADLPIDP NEPTYCLCNQ VSYGEMIGCD. It is sometimes possible for the material contained within the vial of "ING1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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