Western Blot (WB)
(Host: RabbitTarget Name: IL2RGSample Tissue: Human U937 Whole Cell lysatesAntibody Dilution: 1ug/ml)
Rabbit anti-Human IL2RG Polyclonal Antibody | anti-IL2RG antibody
IL2RG Antibody - C-terminal region
Western Blot (WB)
(Host: RabbitTarget Name: IL2RGSample Tissue: Human U937 Whole Cell lysatesAntibody Dilution: 1ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: IL2RGSample Tissue: Human U937 Whole Cell lysatesAntibody Dilution: 1ug/ml)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]
Uniprot Description
IL2RG: Common subunit for the receptors for a variety of interleukins. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell- negative (XSCID); also known as agammaglobulinemia Swiss type. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell- mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Defects in IL2RG are the cause of X-linked combined immunodeficiency (XCID). XCID is a less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID. Belongs to the type I cytokine receptor family. Type 5 subfamily.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: membrane; integral to plasma membrane; plasma membrane; external side of plasma membrane
Molecular Function: protein binding; interleukin-4 receptor activity; interleukin-2 receptor activity; interleukin-7 binding; interleukin-7 receptor activity; interleukin-2 binding
Biological Process: viral reproduction; immune response; signal transduction
Disease: Combined Immunodeficiency, X-linked; Severe Combined Immunodeficiency, X-linked
Research Articles on IL2RG
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Product Notes
The IL2RG il2rg (Catalog #AAA3221491) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IL2RG Antibody - C-terminal region reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IL2RG can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the IL2RG il2rg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: FSAWSGVSKG LAESLQPDYS ERLCLVSEIP PKGGALGEGP GASPCNQHSP. It is sometimes possible for the material contained within the vial of "IL2RG, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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