Structure
AC-265347 Biochemical
AC-265347
Purity
>98% (HPLC)
Synonyms
AC-265347; AC265347; AC-265347 biochemical
Purity/Purification
>98% (HPLC)
Target
CaSR
Receptor
CaSR
Chemical Name
1-(1, 3-benzothiazol-2-yl)-1-(2, 4-dimethylphenyl)ethanol
SMILES
CC(C1=NC2=CC=CC=C2S1)(O)C3=CC=C(C)C=C3C
Molecular Formula
C17H17NOS
CAS Number
1253901-26-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AC-265347 biochemical
AC-265347 is a calcimimetic acting agent and highly efficacious, orally active allosteric agonist (PAM) of CaSR with IC50 of 10nM in PI hydrolysis assays; activates CaSR signaling in cellular proliferation with IC50 of 30nM; significantly stimulates greater responses than Cinacalcet or Calindol at each of four loss-of-function human polymorphic CaSR variants, and does not inhibit the CYP2D6 cytochrome P450 isozyme; reduced serum parathyroid hormone (PTH) in rats, also reduces plasma ionizable calcium ([Ca (2+)] (o)).
Product Categories/Family for AC-265347 biochemical
References
1. Ma JN, et al. J Pharmacol Exp Ther. 2011 Apr; 337 (1):275-84.
2. Cook AE, et al. Br J Pharmacol. 2015 Jan; 172 (1):185-200.
3. Leach K, et al. Cell Res. 2016 May; 26 (5):574-92.
2. Cook AE, et al. Br J Pharmacol. 2015 Jan; 172 (1):185-200.
3. Leach K, et al. Cell Res. 2016 May; 26 (5):574-92.
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Product Notes
The AC-265347 (Catalog #AAA3601021) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AC-265347, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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