Rabbit anti-Human IGF2R Polyclonal Antibody

IGF2R, CT (Cation-independent Mannose-6-phosphate Receptor, CI Man-6-P Receptor, CI-MPR, M6PR, 300kD Mannose 6-phosphate Receptor, MPR 300, Insulin-like Growth Factor 2 Receptor, Insulin-like Growth Factor II Receptor, IGF-II Receptor, M6P/IGF2 Receptor,

Cat. Num. AAA6009219

• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Immunofluorescence
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: IGF2R; Polyclonal Antibody; CT (Cation-independent Mannose-6-phosphate Receptor; CI Man-6-P Receptor; CI-MPR; M6PR; 300kD Mannose 6-phosphate Receptor; MPR 300; Insulin-like Growth Factor 2 Receptor; Insulin-like Growth Factor II Receptor; IGF-II Receptor; M6P/IGF2 Receptor; ; Anti -IGF2R; anti-IGF2R antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human IGF2R. Species sequence homology: mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS (without Mg2+, Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.

• Applicable Applications for anti-IGF2R antibody: ELISA (EL/EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Suitable for use in ELISA, Immunofluorescence and Immunohistochemistry.; Dilution: ELISA: 1:20,000; Immunofluorescence: 1:100-1:500; Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
• Immunogen: Synthetic peptide corresponding to human IGF2R.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunofluorescence (IF)

(Immunofluorescence analysis of HeLa cells, using IGF2R Antibody. The picture on the right is treated with the synthesized peptide.)

Immunohistochemistry (IHC)

(Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-IGF2R antibody

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

Product Categories/Family for anti-IGF2R antibody

Antibodies; Abs to Golgi Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 14210066
• NCBI Official Full Name: IGF2R
• Protein Family: Cation-independent mannose-6-phosphate receptor

NCBI Description

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq, Apr 2013]