Rabbit anti-Human ICOSLG Polyclonal Antibody | anti-ICOSLG antibody

ICOSLG Antibody

Cat. Num. AAA9409849

• Gene Names: ICOSLG; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
• Reactivity: Human
• Applications: Western Blot
• Purity: Antigen affinity purification.
• Synonyms: ICOSLG; Polyclonal Antibody; ICOSLG Antibody; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L; anti-ICOSLG antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total ICOSLG protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 1.3 mg/ml (varies by lot)
• Sequence Length: 309

• Applicable Applications for anti-ICOSLG antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:200-1:1000
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human inducible T-cell co-stimulator ligand
• Target Name: ICOSLG
• Preparation and Storage: Store at -20 degree C

Testing Data

(Gel: 6%SDS-PAGE Lysates (from left to right): Human fetal brain and human lymphoma tissue Amount of lysate: 80ug per lane Primary antibody: 1/100 dilution Secondary antibody dilution: 1/8000 Exposure time: 10 minutes)

Related Product Information for anti-ICOSLG antibody

ICOS ligand is a protein that in humans is encoded by the ICOSLG gene. ICOSLG has also been designated as CD275 (cluster of differentiation 275). Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

Product Categories/Family for anti-ICOSLG antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 545688560
• NCBI GeneID: 23308
• NCBI Accession #: NP_001269979.1
• NCBI GenBank Nucleotide #: NM_001283050.1
• UniProt Accession #: O75144; Q9HD18; Q9NRQ1; A8MUZ1
• Molecular Weight: 20,120 Da
• NCBI Official Full Name: ICOS ligand isoform b
• NCBI Official Synonym Full Names: inducible T-cell co-stimulator ligand
• NCBI Official Symbol: ICOSLG
• NCBI Official Synonym Symbols: B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
• NCBI Protein Information: ICOS ligand
• UniProt Protein Name: ICOS ligand
• Protein Family: ICOS ligand
• UniProt Gene Name: ICOSLG
• UniProt Synonym Gene Names: B7H2; B7RP1; ICOSL; KIAA0653; B7-H2; B7RP-1
• UniProt Entry Name: ICOSL_HUMAN

Uniprot Description

ICOSLG: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function. Belongs to the immunoglobulin superfamily. BTN/MOG family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: receptor binding

Biological Process: hyperosmotic response; T cell activation; B cell activation; T cell costimulation; defense response; signal transduction; positive regulation of activated T cell proliferation