Rabbit ICAM-5 Polyclonal Antibody | anti-ICAM-5 antibody

ICAM-5 Polyclonal Antibody

Cat. Num. AAA3006430

• Gene Names: ICAM5; TLN; TLCN
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: ICAM-5; Polyclonal Antibody; ICAM-5 Polyclonal Antibody; Intercellular adhesion molecule 5; Telencephalin; ICAM5; TLCN; TLN; anti-ICAM-5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ICAM-5 polyclonal antibody detects endogenous levels of ICAM-5 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 924

• Applicable Applications for anti-ICAM-5 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human ICAM-5.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of ICAM-5 polyclonal antibody at 1:500 dilutionLane1:Hela whole cell lysateLane2:Raw264. 7 whole cell lysateLane3:PC12 whole cell lysate)

Related Product Information for anti-ICAM-5 antibody

Cell adhesion molecules are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and are thought to playimportant, yet separate, roles in embryogenesis and development. The intracellular adhesion molecule-1 (ICAM-1), also referred to as CD54, is an integral membrane protein of the immunoglobulin superfamily and recognizes the beta2alpha1 and beta2alphaM integrins. ICAM-2 functions as a ligand for lymphocyte functionassociated antigen-1 (LFA-1) and is involved in leukocyte adhesion. ICAM-3 is highly expressed on the surface of human eosinophils, and when bound to ligand may inhibit eosinophil inflammatory responses and survival. ICAM-4, also known as LW glycoprotein, interacts with the integrins alphaLbeta2, alphaMbeta2, alpha4beta1, the alphaV family and alphaIIbbeta3, and selective binding to different integrins may be relevant to the pathology in a number of red blood cell associated diseases. Lastly, ICAM-5, expressed on telencephalic neurons, binds CD11a/CD18 and thus may act as an adhesion molecule for leukocyte binding in the central nervous system.

NCBI and Uniprot Product Information

• NCBI GI #: 296439327
• NCBI GeneID: 7087
• UniProt Accession #: Q9UMF0
• Molecular Weight: ~ 97kDa
• NCBI Official Full Name: Intercellular adhesion molecule 5
• NCBI Official Synonym Full Names: intercellular adhesion molecule 5
• NCBI Official Symbol: ICAM5
• NCBI Official Synonym Symbols: TLN; TLCN
• NCBI Protein Information: intercellular adhesion molecule 5
• UniProt Protein Name: Intercellular adhesion molecule 5
• UniProt Gene Name: ICAM5
• UniProt Synonym Gene Names: TLCN; TLN; ICAM-5
• UniProt Entry Name: ICAM5_HUMAN

NCBI Description

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]

Uniprot Description

ICAM5: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). Belongs to the immunoglobulin superfamily. ICAM family.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: integrin binding; protein binding

Biological Process: cell-cell adhesion; cell adhesion; phagocytosis