Human ICAM-5 ELISA Kit | ICAM5 elisa kit

Human ICAM-5 ELISA Kit

Cat. Num. AAA8248362

• Gene Names: ICAM5; TLN; TLCN
• Reactivity: Human
• Synonyms: ICAM-5; Human ICAM-5 ELISA Kit; TLCN; TLN; Intercellular adhesion molecule 5; Telencephalin; ICAM5 elisa kit

• Reactivity: Human
• Specificity: The Human ICAM-5 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human ICAM-5 proteins within the range of 156 pg/ml - 10000 pg/ml.
• Sequence Length: 924

• Samples: Cell Culture Supernates, Serum, Plasma
• Sensitivity: <15 pg/ml
• Preparation and Storage: Shipped and store at 4 degree C for 6 months, store at -20 degree C for one year. Avoid freeze/thaw cycles.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for ICAM5 elisa kit

Principle of the Assay: The Human ICAM-5 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Human ICAM-5 in Cell Culture Supernates, Serum, Plasma. This assay employs an antibody specific for Human ICAM-5 coated on a 96-well plate. Standards and samples are pipetted into the wells and ICAM-5 present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-Human ICAM-5 antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of ICAM-5 bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm.

Background: Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene. The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.

NCBI and Uniprot Product Information

• NCBI GI #: 189571583
• NCBI GeneID: 7087
• NCBI Accession #: NP_003250.3
• NCBI GenBank Nucleotide #: NM_003259.3
• UniProt Accession #: Q9UMF0; Q9Y6F3
• Molecular Weight: 97,116 Da
• NCBI Official Full Name: intercellular adhesion molecule 5
• NCBI Official Synonym Full Names: intercellular adhesion molecule 5
• NCBI Official Symbol: ICAM5
• NCBI Official Synonym Symbols: TLN; TLCN
• NCBI Protein Information: intercellular adhesion molecule 5
• UniProt Protein Name: Intercellular adhesion molecule 5
• Protein Family: Intercellular adhesion molecule
• UniProt Gene Name: ICAM5
• UniProt Synonym Gene Names: TLCN; TLN; ICAM-5
• UniProt Entry Name: ICAM5_HUMAN

NCBI Description

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]

Uniprot Description

ICAM5: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). Belongs to the immunoglobulin superfamily. ICAM family.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: integrin binding; protein binding

Biological Process: cell adhesion; extracellular matrix organization and biogenesis; regulation of immune response