Rabbit anti-Human, Mouse IBP160 Polyclonal Antibody | anti-AQR antibody

IBP160 Antibody

Cat. Num. AAA9629690

• Gene Names: AQR; IBP160; fSAP164
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: IBP160; Polyclonal Antibody; IBP160 Antibody; AQR; AQR_HUMAN; aquarius; aquarius homolog (mouse); Aquarius intron binding spliceosomal factor; DKFZp686B23123; fSAP164; functional spliceosome-associated protein 164; Intron-binding protein aquarius; Intron-binding protein of 160 kDa; KIAA0560; anti-AQR antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: IBP160 Antibody detects endogenous levels of total IBP160.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-AQR antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: Contains an N-terminal domain with structural similarity to ARM repeat regions; this domain functions as scaffold for protein-protein interactions, but is not required for RNA binding or for ATP-dependent RNA helicase activity. Belongs to the CWF11 family.
• Subunit Structure: Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19. Within the spliceosome, interacts with SNRPA1, SF3B1, SF3B3, SF3A1 and SF3A2.
• Function: Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro).
• Note: Localizes to speckle-like regions of the nucleoplasm.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-AQR antibody

Nucleus; Nucleoplasm; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 38788372
• NCBI GeneID: 9716
• NCBI Accession #: NP_055506
• NCBI GenBank Nucleotide #: NM_014691.2
• UniProt Accession #: O60306; Q2YDX9; Q6IRU8; Q6PIC8; A0JP17; A5YKK3
• Molecular Weight: 171,295 Da
• NCBI Official Full Name: intron-binding protein aquarius
• NCBI Official Synonym Full Names: aquarius intron-binding spliceosomal factor
• NCBI Official Symbol: AQR
• NCBI Official Synonym Symbols: IBP160; fSAP164
• NCBI Protein Information: intron-binding protein aquarius
• UniProt Protein Name: Intron-binding protein aquarius
• Protein Family: Intron-binding protein aquarius
• UniProt Gene Name: AQR
• UniProt Synonym Gene Names: KIAA0560; IBP160
• UniProt Entry Name: AQR_HUMAN

Uniprot Description

AQR: Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Belongs to the CWF11 family.

Protein type: RNA-binding; Spliceosome; RNA splicing

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: membrane; nucleoplasm

Molecular Function: protein binding

Biological Process: nuclear mRNA splicing, via spliceosome; transcription-coupled nucleotide-excision repair