Testing Data
Rabbit anti-Mouse, Rat HNF-4 Polyclonal Antibody | anti-HNF-4 antibody
HNF-4 Antibody
Appearance: Colorless liquid
Shelf Life: 12 months
Testing Data
Testing Data
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a transcription factor involved in the development of the pancreas, liver, kidney, and intestines. The encoded protein also functions to maintain glucose homeostasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Description
HNF4 alpha: a nuclear transcription factor which binds DNA as a homodimer. Controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic gene, alpha 1-antitrypsin, apolipoprotein CIII, and transthyretin genes. May be essential for development of the liver, kidney and intestine. Mutations have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Four alternatively spliced isoforms have been described.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Cellular Component: transcription factor complex; cytoplasm; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; ligand-dependent nuclear receptor activity; protein homodimerization activity; acyl-CoA binding; zinc ion binding; metal ion binding; transcription factor binding; protein binding; DNA binding; sequence-specific DNA binding; steroid hormone receptor activity; fatty acid binding; transcription factor activity; palmitoyl-CoA hydrolase activity; receptor binding
Biological Process: transcription from RNA polymerase II promoter; acyl-CoA metabolic process; regulation of lipid metabolic process; positive regulation of transcription, DNA-dependent; lipid homeostasis; negative regulation of tyrosine phosphorylation of Stat5 protein; glucose homeostasis; positive regulation of gluconeogenesis; negative regulation of cell proliferation; negative regulation of protein import into nucleus, translocation; regulation of transcription, DNA-dependent; regulation of gastrulation; response to glucose stimulus; negative regulation of mitotic cell cycle; cell differentiation; regulation of microvillus biogenesis; phospholipid homeostasis; intercellular junction assembly and maintenance; positive regulation of fatty acid biosynthetic process; transcription, DNA-dependent; establishment of tissue polarity; negative regulation of transcription factor activity; regulation of transcription from RNA polymerase II promoter; xenobiotic metabolic process; ornithine metabolic process; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; lipid metabolic process; negative regulation of cell growth; blood coagulation; sex differentiation; regulation of insulin secretion
Research Articles on HNF-4
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Product Notes
The HNF-4 hnf4a (Catalog #AAA840282) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HNF-4 Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HNF-4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting (0.5-4 ug/ml). However, the optimal concentrations should be determined individually. Mouse small intestine and rat kidney tissue lysates can be used as positive controls. Researchers should empirically determine the suitability of the HNF-4 hnf4a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HNF-4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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