Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Human Hairy And Enhancer Of Split 1 Polyclonal Antibody | anti-HES1 antibody
Polyclonal Antibody to Hairy And Enhancer Of Split 1 (HES1)
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded Kidney tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded Kidney tissue))
NCBI and Uniprot Product Information
NCBI Description
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]
Uniprot Description
HES1: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 3q29
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: chaperone binding; DNA binding; DNA binding transcription factor activity; histone deacetylase binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription factor binding
Biological Process: adenohypophysis development; artery morphogenesis; auditory receptor cell fate determination; cell adhesion; cell maturation; cell migration; cell morphogenesis involved in neuron differentiation; hindbrain morphogenesis; inner ear receptor stereocilium organization and biogenesis; lateral inhibition; liver development; lung development; midbrain development; midbrain-hindbrain boundary morphogenesis; negative regulation of auditory receptor cell differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nervous system development; Notch signaling pathway; oculomotor nerve development; pancreas development; positive regulation of astrocyte differentiation; positive regulation of BMP signaling pathway; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of JAK-STAT cascade; positive regulation of mitotic cell cycle, embryonic; positive regulation of Notch signaling pathway; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of STAT protein; protein complex assembly; radial glial cell differentiation in the forebrain; regulation of epithelial cell proliferation; regulation of fat cell differentiation; regulation of timing of neuron differentiation; smoothened signaling pathway; somatic stem cell maintenance; STAT protein import into nucleus; telencephalon development; thymus development; transcription, DNA-dependent; trochlear nerve development
Research Articles on HES1
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Product Notes
The HES1 hes1 (Catalog #AAA2028453) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Hairy And Enhancer Of Split 1 (HES1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Hairy And Enhancer Of Split 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.2-2ug/mL;1:250-2500 Immunohistochemistry: 5-20ug/mL;1:25-100 Immunocytochemistry: 5-20ug/mL;1:25-100 Optimal working dilutions must be determined by end user. . Researchers should empirically determine the suitability of the HES1 hes1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Hairy And Enhancer Of Split 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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