Rabbit Grik4 Polyclonal Antibody | anti-GRIK4 antibody

Grik4, NT (Glutamate receptor ionotropic kainate 4 precursor, EAA1, Excitatory amino acid receptor 1, Glutamate receptor KA-1, GRIK, KA1)

Cat. Num. AAA619238

• Gene Names: GRIK4; KA1; EAA1; GRIK
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Grik4; Polyclonal Antibody; NT (Glutamate receptor ionotropic kainate 4 precursor; EAA1; Excitatory amino acid receptor 1; Glutamate receptor KA-1; GRIK; KA1); Anti -Grik4; anti-GRIK4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Grik4. Species crossreactivity: Mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-GRIK4 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 0.5-1ug/ml
• Immunogen: Synthetic peptide corresponding to 14aa from near the amino terminus of the human Grik4 (GenBank accession no. Q16099).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot analysis of Grik4 in Rat brain tissue lysate with Grik4 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.)

Related Product Information for anti-GRIK4 antibody

Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons (1,2). Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits (2,3). In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA- containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling (3). KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder (4,5). Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE.

Product Categories/Family for anti-GRIK4 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 29029595
• NCBI GeneID: 2900
• NCBI Accession #: NP_055434.2
• NCBI GenBank Nucleotide #: NM_014619.2
• UniProt Accession #: Q16099; A8K9L1; Q3C1X2
• Molecular Weight: 107,246 Da
• NCBI Official Full Name: glutamate receptor, ionotropic kainate 4
• NCBI Official Synonym Full Names: glutamate receptor, ionotropic, kainate 4
• NCBI Official Symbol: GRIK4
• NCBI Official Synonym Symbols: KA1; EAA1; GRIK
• NCBI Protein Information: glutamate receptor, ionotropic kainate 4; OTTHUMP00000045951; OTTHUMP00000231881; glutamate receptor KA1; glutamate receptor KA-1; excitatory amino acid receptor 1
• UniProt Protein Name: Glutamate receptor, ionotropic kainate 4
• Protein Family: Glutamate receptor ionotropic
• UniProt Gene Name: GRIK4
• UniProt Synonym Gene Names: GRIK
• UniProt Entry Name: GRIK4_HUMAN

NCBI Description

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. [provided by RefSeq]

Uniprot Description

GluR KA1: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.

Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; integral to plasma membrane; dendrite; plasma membrane; terminal button; perikaryon; cell junction; nucleus

Molecular Function: extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity

Biological Process: synaptic transmission, glutamatergic; synaptic transmission; transport; ionotropic glutamate receptor signaling pathway; glutamate signaling pathway; response to corticosteroid stimulus