Rabbit anti-Human CD300b Polyclonal Antibody | anti-CD300b antibody

CD300b Rabbit pAb

Cat. Num. AAA4755178

• Gene Names: CD300LB; CLM7; CLM-7; IREM3; TREM5; CD300b; IREM-3; TREM-5; CMRF35-A2
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Affinity purified
• Synonyms: CD300b; Polyclonal Antibody; CD300b Rabbit pAb; CMRF35-like molecule 7 (CLM-7) (CD300 antigen-like family member B) (CMRF35-A2) (Immune receptor expressed on myeloid cells 3) (IREM-3) (Leukocyte mono-Ig-like receptor 5) (Triggering receptor expressed on myeloid cells 5) (TREM-5) (CD antigen CD300b); anti-CD300b antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous CD300b
• Purity/Purification: Affinity purified
• Form/Format: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-CD300b antibody: Immunohistochemistry-Paraffin (IHC-P), ELISA (EIA)
• Application Notes: IHC-P: 1:50-1:200; ELISA: 1:10,000-1:20,000
• Immunogen: Synthetic peptide from human protein at AA range: 61-110
• Conjugation: Unconjugated
• Nucleotide Accession: 124599
• Modification: Unmodified
• Cell Position: Cell membrane, Membrane
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human-liver-cancer, antibody was diluted at 1:200)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human-liver-cancer, antibody was diluted at 1:200)

Product Categories/Family for anti-CD300b antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 510936990
• NCBI GeneID: 124599
• NCBI Accession #: NP_777552.3
• NCBI GenBank Nucleotide #: NM_174892.3
• UniProt Accession #: A8K4G0; Q1EG73; Q8IX40; Q8N6D1
• Molecular Weight: 22,689 Da
• NCBI Official Full Name: CMRF35-like molecule 7
• NCBI Official Synonym Full Names: CD300 molecule-like family member b
• NCBI Official Symbol: CD300LB
• NCBI Official Synonym Symbols: CLM7; CLM-7; IREM3; TREM5; CD300b; IREM-3; TREM-5; CMRF35-A2
• NCBI Protein Information: CMRF35-like molecule 7; leukocyte mono-Ig-like receptor 5; CD300 antigen like family member B; immune receptor expressed on myeloid cells 3; triggering receptor expressed on myeloid cells 5
• UniProt Protein Name: CMRF35-like molecule 7
• UniProt Gene Name: CD300LB
• UniProt Synonym Gene Names: CD300B; CLM7; CMRF35A2; IREM3; LMIR5; TREM5; CLM-7; IREM-3; TREM-5
• UniProt Entry Name: CLM7_HUMAN

NCBI Description

CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008]

Uniprot Description

Function: Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. Ref.1 Ref.9

Subunit structure: Interacts with TYROBP, which enhances cell surface expression and activation properties. Interacts with GRB2 in the presence of FYN. Ref.1 Ref.9

Subcellular location: Cell membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Expressed exclusively in myeloid lineages. Ref.1

Post-translational modification: Phosphorylation on Tyr-188 by FYN is required for interaction with GRB2.

Sequence similarities: Belongs to the CD300 family.Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Sequence caution: The sequence AAH28091.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence BAF83614.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence EAW89170.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.