Rabbit anti-Human GPR4 Polyclonal Antibody | anti-GPR4 antibody
GPR4
Reactivity
Human
Applications
Western Blot
Purity
Antigen Immunoaffiinity Purification
Synonyms
GPR4; Polyclonal Antibody; anti-GPR4 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Immunoaffiinity Purification
Form/Format
Provided as ligand affinity purified antibody in phosphate buffered saline with 0.08% sodium azide
Sequence Length
362
Applicable Applications for anti-GPR4 antibody
Western Blot (WB)
Immunogen
Synthetic peptide derived from the GPR4 protein.
Positive Control
Human brain lysate(
Preparation and Storage
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Related Product Information for anti-GPR4 antibody
Sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC) are bioactive lipid molecules involved in numerous biologicals processes. GPR4 shares sequence homology with OGR1 (51%), the highest of all GPCR?s. GPR4 has been identified as another high affinity receptor for SPC and low affinity receptor for LPC. SPC and LPC stimulate kinase activation and DNA synthesis stimulated, both of which are pertussis toxin-sensitive, suggesting Gi-heterotrimeric G protein involvement. The GPR4 subfamily of GPCR?s consists of four receptors that share significant sequence homology; OGR1, TDAG8 and G2A. G2A has been shown to be a potent transforming oncogene. GPR4 also malignantly transforms NIH3T3 cells and TDAG8 malignantly transforms the normal mammary epithelial cell line NMuMG. Overexpression of GPR4 or TDGA8 in HEK293 cells leads to transcriptional activation independent of exogenously added ligand. TDAG8 and GPR4 are also overexpressed in a range of human cancer tissues suggestive of a driving role in maintaining tumor formation.
Product Categories/Family for anti-GPR4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
40,982 Da
NCBI Official Full Name
G-protein coupled receptor 4
NCBI Official Synonym Full Names
G protein-coupled receptor 4
NCBI Official Symbol
GPR4
NCBI Protein Information
G-protein coupled receptor 4; G-protein coupled receptor 19
UniProt Protein Name
G-protein coupled receptor 4
Protein Family
UniProt Gene Name
GPR4
UniProt Synonym Gene Names
GPR19
UniProt Entry Name
GPR4_HUMAN
Uniprot Description
Function: Proton-sensing receptor coupled to several G-proteins, including G(s), G13 and G(q)/G11 proteins, leading to cAMP production. Ref.9 Ref.11 Ref.12
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Sequence caution: The sequence AAA63180.1 differs from that shown. Reason: Frameshift at position 347.
Research Articles on GPR4
Similar Products
Product Notes
The GPR4 gpr4 (Catalog #AAA395755) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GPR4 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GPR4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the GPR4 gpr4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GPR4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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