Western Blot/Blotting
(Western blot analysis using PAP2B antibody on human brain lysate.)
Rabbit Phosphatidic Acid Phosphatase 2B Polyclonal Antibody | anti-PPAP2B antibody
Phosphatidic Acid Phosphatase 2B
Western Blot/Blotting
(Western blot analysis using PAP2B antibody on human brain lysate.)
Western Blot/Blotting
(Western blot analysis using PAP2B antibody on human brain lysate.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]
Uniprot Description
Function: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.
Catalytic activity: A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
Enzyme regulation: Inhibited by sphingosine, zinc ions and propanolol. Not inhibited by N-ethylmaleimide treatment.
Subunit structure: Homodimer. This complex seems not to be involved in substrate recognition, it may confer only structural or functional stability. Ref.9
Subcellular location: Golgi apparatus › trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue specificity: Ubiquitously expressed. Highly expressed in heart and placenta.
Induction: By EGF, VEGF, FGF2 and phorbol myristate acetate (PMA). Ref.1
Post-translational modification: N-glycosylated. Contains high-mannose oligosaccharides.
Sequence similarities: Belongs to the PA-phosphatase related phosphoesterase family.
Sequence caution: The sequence AAB50222.1 differs from that shown. Reason: Frameshift at position 225.
Research Articles on PPAP2B
Similar Products
Product Notes
The PPAP2B ppap2b (Catalog #AAA395975) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phosphatidic Acid Phosphatase 2B reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Phosphatidic Acid Phosphatase 2B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). Researchers should empirically determine the suitability of the PPAP2B ppap2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Phosphatidic Acid Phosphatase 2B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
