Rabbit anti-Human GPLD1 Polyclonal Antibody | anti-GPLD1 antibody

GPLD1, NT (Phosphatidylinositol-glycan-specific Phospholipase D, PI-G PLD, Glycoprotein Phospholipase D, Glycosyl-phosphatidylinositol-specific Phospholipase D, GPI-specific Phospholipase D, GPI-PLD, PIGPLD1)

Cat. Num. AAA629250

• Gene Names: GPLD1; GPIPLD; PIGPLD; GPIPLDM; PIGPLD1
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: GPLD1; Polyclonal Antibody; NT (Phosphatidylinositol-glycan-specific Phospholipase D; PI-G PLD; Glycoprotein Phospholipase D; Glycosyl-phosphatidylinositol-specific Phospholipase D; GPI-specific Phospholipase D; GPI-PLD; PIGPLD1); Anti -GPLD1; anti-GPLD1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human GPLD1.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-GPLD1 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:1,000; Immunohistochemistry: 1:50-1:100
• Immunogen: Synthetic peptide selected from the N-terminal region of human GPLD1 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-GPLD1 antibody

Glycosylation is one of the most universal but at the same time complex protein modifications. Modification with sugar moeties can be both co- translational and post- translational, occurring in the endoplasmatic reticulum and golgi. Three different forms of glycosylation can be distinguished: N-linked oligosaccharides, O-linked oligosaccharides and glycosyl- phosphatidylinositol (GPI-) anchors. Glycosylation results in thousands of distinct, bioactive glycoproteins resident throughout the cell that strongly determine protein-protein, carbohydrate-protein, membrane, and adhesion properties. Diseases associated with glycosylation defects include Congenital disorders of glycosylation, (CDG), also known as carbohydrate deficient glycoprotein syndromes, and diseases associated with advanced aging.

Product Categories/Family for anti-GPLD1 antibody

Antibodies; Abs to Enzymes; Phospholipase

NCBI and Uniprot Product Information

• NCBI GI #: 20269065
• NCBI GeneID: 2822
• UniProt Accession #: P80108; Q15127; Q15128; Q2M2F2; Q5T3Y0; Q7Z6T8; Q8TCV0; Q8WW82; Q96ID6; Q9H167; Q9H4M1; Q9UJC9
• Molecular Weight: 92,336 Da
• NCBI Official Full Name: glycosylphosphatidylinositol phospholipase D
• NCBI Official Synonym Full Names: glycosylphosphatidylinositol specific phospholipase D1
• NCBI Official Symbol: GPLD1
• NCBI Official Synonym Symbols: GPIPLD; PIGPLD; GPIPLDM; PIGPLD1
• NCBI Protein Information: phosphatidylinositol-glycan-specific phospholipase D; GPI-PLD; PI-G PLD; GPI-specific phospholipase D; glycoprotein phospholipase D; glycosylphosphatidylinositol specific phospholipase D1, isoform 2
• UniProt Protein Name: Phosphatidylinositol-glycan-specific phospholipase D
• Protein Family: Phosphatidylinositol-glycan-specific phospholipase
• UniProt Gene Name: GPLD1
• UniProt Synonym Gene Names: PIGPLD1; PI-G PLD; GPI-PLD
• UniProt Entry Name: PHLD_HUMAN

NCBI Description

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]

Uniprot Description

GPLD1: This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. Belongs to the GPLD1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Secreted; Phospholipase; EC 3.1.4.50

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: extracellular space; proteinaceous extracellular matrix; intracellular membrane-bound organelle; lysosomal membrane; cytoplasm; intracellular

Molecular Function: glycosylphosphatidylinositol phospholipase D activity; sodium channel regulator activity; phospholipase D activity

Biological Process: ossification; GPI anchor release; positive regulation of apoptosis; complement receptor mediated signaling pathway; positive regulation of membrane protein ectodomain proteolysis; phosphatidylcholine metabolic process; negative regulation of cell proliferation; cell migration during sprouting angiogenesis; cellular response to insulin stimulus; response to glucose stimulus; insulin receptor signaling pathway; chondrocyte differentiation; positive regulation of secretion; positive regulation of cytolysis