Rabbit anti-Mouse Gpihbp1 Polyclonal Antibody | anti-GPIHBP1 antibody

Gpihbp1 (GPI-anchored HDL-binding protein 1, GPI-anchored High-Density Lipid-binding protein 1, GlycosylPhosphatidylInositol-anchored high-density lipoprotein-binding protein 1)

Cat. Num. AAA612810

• Gene Names: GPIHBP1; GPI-HBP1
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Gpihbp1; Polyclonal Antibody; Gpihbp1 (GPI-anchored HDL-binding protein 1; GPI-anchored High-Density Lipid-binding protein 1; GlycosylPhosphatidylInositol-anchored high-density lipoprotein-binding protein 1); Anti -Gpihbp1 (GPI-anchored HDL-binding protein 1; anti-GPIHBP1 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Specificity: Species Crossreactivity: This antibody reacts with mouse protein. Other species have not been tested.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2.

• Applicable Applications for anti-GPIHBP1 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: A synthetic peptide within an internal region [residues 100-200] of the mouse GPI-anchored HDL-binding protein 1 protein. [Swiss-Prot# Q9D1N2]. Homology: 100% with mouse. 86% with rat.
• Positive Control: Mouse kidney lysate
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-GPIHBP1 antibody

GPI-anchored HDL-binding protein 1 (Gpihbp1) is a novel protein that may be involved in the regulation of the delivery of fats to cells for energy and storage. Digested fats travel to the small intestine, where they are packaged into chylomicrons (particles filled with triglycerides). Chylomicrons then travel through the bloodstream and deliver triglycerides to tissues that are hungry for fuel or to adipose tissue for energy storage. Triglycerides are broken down or hydrolyzed by the enzyme lipoprotein lipase (LpL). The triglyceride breakdown products are then taken up and used by cells. Gpihbp1 is the molecule in capillaries that facilitates the capture of chylomicrons and facilitates the interaction with LpL. It has been shown that fats in the bloodstream are not readily metabolized in the absence of GPIHBP1.

Product Categories/Family for anti-GPIHBP1 antibody

Antibodies; Abs to Obesity Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 30794264
• NCBI GeneID: 338328
• NCBI Accession #: NP_835466.1
• NCBI GenBank Nucleotide #: NM_178172.3
• UniProt Accession #: Q8IV16; Q6P3T2; Q86W15
• Molecular Weight: 19,806 Da
• NCBI Official Full Name: glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1
• NCBI Official Synonym Full Names: glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
• NCBI Official Symbol: GPIHBP1
• NCBI Official Synonym Symbols: GPI-HBP1
• NCBI Protein Information: glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; OTTHUMP00000228001; GPI-anchored HDL-binding protein 1; GPI anchored high density lipoprotein binding protein 1
• UniProt Protein Name: Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1
• Protein Family: Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein
• UniProt Gene Name: GPIHBP1
• UniProt Synonym Gene Names: HBP1
• UniProt Entry Name: HDBP1_HUMAN

NCBI Description

Dietary fats are packaged by intestine into triglyceride-rich lipoproteins called chylomicrons. The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LPL: MIM 609708) along the luminal surface of capillaries, mainly in heart, skeletal muscle, and adipose tissue. GPIHBP1 is a capillary endothelial cell protein that provides a platform for LPL-mediated processing of chylomicrons (Beigneux et al., 2007 [PubMed 17403372]).[supplied by OMIM]

Uniprot Description

GPIHBP1: Plays a key role in the lipolytic processing of chylomicrons.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: anchored to external side of plasma membrane; basolateral plasma membrane; apical plasma membrane; external side of plasma membrane

Molecular Function: protein transmembrane transporter activity; high-density lipoprotein binding; lipid binding

Biological Process: intracellular protein transport; cholesterol homeostasis; protein stabilization; protein import; positive regulation of lipoprotein lipase activity; transcytosis; lipid transport

Disease: Hyperlipoproteinemia, Type Id