GPIHBP1 recombinant protein

Recombinant Human GPIHBP1 (C-Fc)

Cat. Num. AAA2569110

• Gene Names: GPIHBP1; HYPL1D; GPI-HBP1
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: GPIHBP1; Recombinant Human GPIHBP1 (C-Fc); glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein1; GPI anchored high density lipoprotein binding protein 1; GPI-Anchored HDL-Binding Protein 1; GPI-HBP1; GPI-HBP1LOC338328; HBP1; High density lipoprotein-binding protein 1; HYPL1D; GPIHBP1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Thr22-Gly151

• Species: Human
• Tag: C-Fc
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Human Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 is produced by our Mammalian expression system and the target gene encoding Thr22-Gly151 is expressed with a Fc tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for GPIHBP1 recombinant protein

Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) is a member of the Ly6 family of proteins, binds LPL in the subendothelial spaces and transports it to the capillary lumen. GPIHBP1 is an important regulator of triglyceride metabolism by increasing the efficiency of lydrolysis by LPL and uptake of fatty acids. GPIHBP1 was positively correlated with LPL, and GPIHBP1 is a better marker for body weight decrease than LPL.

Product Categories/Family for GPIHBP1 recombinant protein

Signal Transduction; Cardiovascular; metabolism

NCBI and Uniprot Product Information

• NCBI GI #: 684179339
• NCBI GeneID: 338328
• NCBI Accession #: NP_001288701.1
• NCBI GenBank Nucleotide #: NM_001301772.1
• UniProt Accession #: Q8IV16; Q6P3T2; Q86W15
• Molecular Weight: 19,806 Da
• NCBI Official Full Name: glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform 2
• NCBI Official Synonym Full Names: glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
• NCBI Official Symbol: GPIHBP1
• NCBI Official Synonym Symbols: HYPL1D; GPI-HBP1
• NCBI Protein Information: glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1
• UniProt Protein Name: Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1
• Protein Family: Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein
• UniProt Gene Name: GPIHBP1
• UniProt Synonym Gene Names: HBP1; GPI-HBP1; GPI-anchored HDL-binding protein 1

NCBI Description

This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Uniprot Description

GPIHBP1: Plays a key role in the lipolytic processing of chylomicrons.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: anchored component of external side of plasma membrane; apical plasma membrane; basolateral plasma membrane; external side of plasma membrane; extracellular region; intracellular; plasma membrane

Molecular Function: high-density lipoprotein particle binding; lipid binding; protein transmembrane transporter activity

Biological Process: C-terminal protein lipidation; cholesterol homeostasis; intracellular protein transport; lipid transport; positive regulation of lipoprotein lipase activity; protein import; protein stabilization; regulation of lipoprotein lipase activity; retinoid metabolic process; transcytosis

Disease: Hyperlipoproteinemia, Type Id