Immunohistochemistry (IHC)
(Immunohistochemistry analysis of human spleen tissue stained with PDI, pAb at 10µg/ml.)
Rabbit PDI Polyclonal Antibody | anti-P4HB; protein disulfide isomerase antibody
PDI polyclonal antibody
Gene Names
P4HB; PDI
Reactivity
Human, Mouse, Rat, Bovine, Dog, Guinea pig, Hamster, Monkey, Porcine, Sheep, Xenopus
Applications
Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Purity
Protein A affinity purified.
Synonyms
PDI; Polyclonal Antibody; PDI polyclonal antibody; anti-P4HB; protein disulfide isomerase antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat, Bovine, Dog, Guinea pig, Hamster, Monkey, Porcine, Sheep, Xenopus
Clonality
Polyclonal
Specificity
Recognizes human, mouse, rat, bovine, dog, guinea pig, hamster, monkey, pig, sheep and Xenopus PDI. Detects a band of ~58kDa by Western blot.
Purity/Purification
Protein A affinity purified.
Form/Format
Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
Sequence Length
510
Applicable Applications for anti-P4HB; protein disulfide isomerase antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) Paraffin, Immunoprecipitation (IP), Western Blot (WB)
Application Notes
Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Detects a band of ~58kDa by Western blot.
Suggested dilutions/conditions may not be available for all applications.
Detects a band of ~58kDa by Western blot.
Immunogen
Purified bovine liver Protein Disulfide Isomerase.
Preparation and Storage
Long term storage: -20 degree C
Avoid freeze/thaw cycles.
Avoid freeze/thaw cycles.
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of human spleen tissue stained with PDI, pAb at 10µg/ml.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of human spleen tissue stained with PDI, pAb at 10µg/ml.)
Related Product Information for anti-P4HB; protein disulfide isomerase antibody
The mammalian PDI (Protein disulfide-isomerase) family encompasses several highly divergent proteins which are involved in the processing and maturation of secretory proteins in the endoplasmic reticulum by catalyzing the rearrangement of disulfide bonds.
Product Categories/Family for anti-P4HB; protein disulfide isomerase antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
57,266 Da
NCBI Official Full Name
Protein disulfide-isomerase
NCBI Official Symbol
P4HB
NCBI Official Synonym Symbols
PDI
NCBI Protein Information
protein disulfide-isomerase
UniProt Protein Name
Protein disulfide-isomerase
UniProt Gene Name
P4HB
UniProt Synonym Gene Names
PDIA1; PDI
UniProt Entry Name
PDIA1_BOVIN
Uniprot Description
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
Research Articles on P4HB; protein disulfide isomerase
Similar Products
Product Notes
The P4HB; protein disulfide isomerase p4hb (Catalog #AAA565370) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PDI polyclonal antibody reacts with Human, Mouse, Rat, Bovine, Dog, Guinea pig, Hamster, Monkey, Porcine, Sheep, Xenopus and may cross-react with other species as described in the data sheet. AAA Biotech's PDI can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) Paraffin, Immunoprecipitation (IP), Western Blot (WB). Western Blot (1:1,000, colorimetric) Suggested dilutions/conditions may not be available for all applications. Detects a band of ~58kDa by Western blot. Researchers should empirically determine the suitability of the P4HB; protein disulfide isomerase p4hb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PDI, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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