Mouse anti-Human GMCL1L Polyclonal Antibody | anti-GMCL1P1 antibody

GMCL1L (GCL, GMCL1L, Putative Germ Cell-less Protein-like 1-like)

Cat. Num. AAA649715

• Gene Names: GMCL1P1; GCL; GMCL2; GMCL1L
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: GMCL1L; Polyclonal Antibody; GMCL1L (GCL; Putative Germ Cell-less Protein-like 1-like); Anti -GMCL1L (GCL; anti-GMCL1P1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human GMCL1L.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MGSSSSRVLGQPRRALAQQEQGARARGSARRPDTGDDAASYGFCYCPGSHKRKRSSGACRYCDPDSHREEHEEEGDKQQPLLNTPARKKLRSTSKYIYQTLFLNGENSDIKICALGEEWRLHKIYLCQSGYFSSMFSGSWKESSMNIIELEIPDQNIDVDALQVAFGSLYRDDVLIKPSRVVAILAAACMLQLDGLIQQCGETMKETINVKTVCGYYTSVEIYGLDSVKKKCLEWLLNNLMTHQNVKLFKELGINVMKQLIGSSNLFVMQVEMDVYTTLKKWMFLQLVPSWNGSLKQLLTETDVWFSKQRKDFEGMAFLETEPGKPFVSVFRHLRLQYIISDLASARIIEQDGIVPSEWLSSVYKQQWFAMLRAEQDHEVGPQEINKEDLEGSSMRCGRKLAKDGEYYWCWTGFNFGFDLLVIYTNGYIIFKRNTLNQPCSGSVSLRPRRSIAFRLRLASFDSSGKLVCSRTTGYQILILKKDQEQVVMNLDSRFLTFPLYICCNFLYISPEKGIENNRHPEDPEN

• Applicable Applications for anti-GMCL1P1 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human GMCL1L, aa1-526 (AAH33886.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of GMCL1L expression in transfected 293T cell line by GMCL1L polyclonal antibody. Lane 1: GMCL1L transfected lysate (57.86kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-GMCL1P1 antibody

Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport. Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Product Categories/Family for anti-GMCL1P1 antibody

Antibodies; Abs to Spermatogenesis; Testis Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 119574231
• NCBI GeneID: 64396
• UniProt Accession #: Q8NEA9; Q8TC88; Q8TC89; B2RDW6
• Molecular Weight: 60,201 Da
• NCBI Official Full Name: germ cell-less homolog 1 (Drosophila)-like
• NCBI Official Synonym Full Names: germ cell-less, spermatogenesis associated 1 pseudogene 1
• NCBI Official Symbol: GMCL1P1
• NCBI Official Synonym Symbols: GCL; GMCL2; GMCL1L
• UniProt Protein Name: Putative germ cell-less protein-like 1-like
• Protein Family: Putative germ cell-less protein
• UniProt Gene Name: GMCL1P1
• UniProt Synonym Gene Names: GCL; GMCL1L
• UniProt Entry Name: GMCLL_HUMAN

NCBI Description

This locus shares a high degree of identity with the multi-exon germ cell-less gene on chromosome 2. Despite its single-exon nature, this chromosome 5 locus contains an open reading frame that could putatively encode a full-length germ cell-less related protein. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport

By similarity. Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ref.3

Pathway: Protein modification; protein ubiquitination.

Subunit structure: Interacts with TMPO-Beta, TSG101 and TFDP2. Interacts with EMD

By similarity. Interacts with CUL3. Ref.3

Subcellular location: Nucleus matrix

By similarity.

Sequence similarities: Contains 1 BTB (POZ) domain.