Rabbit anti-Human GMCL1L Polyclonal Antibody | anti-GMCL1L antibody

GMCL1L, CT (GMCL1P1, GCL, GMCL1L, Putative germ cell-less protein-like 1-like) (FITC)

Cat. Num. AAA6302801

• Gene Names: GMCL1P1; GCL; GMCL2; GMCL1L
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: GMCL1L; Polyclonal Antibody; CT (GMCL1P1; GCL; Putative germ cell-less protein-like 1-like) (FITC); GMCL1P1; Putative germ cell-less protein-like 1-like; anti-GMCL1L antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-GMCL1L antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: GMCL1L antibody is generated from rabbits immunized with a KLH conjugated synthetic between 497-524 amino acids selected from the C-terminal region of human GMCL1L.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(GMCL1L Antibody (C-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the GMCL1L antibody detected the GMCL1L protein (arrow).)

Related Product Information for anti-GMCL1L antibody

GMCL1L is possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Product Categories/Family for anti-GMCL1L antibody

Antibodies; Spermatogenesis; Testis Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 119574231
• NCBI GeneID: 64396
• UniProt Accession #: Q8NEA9; Q8TC88; Q8TC89; B2RDW6
• Molecular Weight: 60,201 Da
• NCBI Official Full Name: germ cell-less homolog 1 (Drosophila)-like
• NCBI Official Synonym Full Names: germ cell-less, spermatogenesis associated 1 pseudogene 1
• NCBI Official Symbol: GMCL1P1
• NCBI Official Synonym Symbols: GCL; GMCL2; GMCL1L
• UniProt Protein Name: Putative germ cell-less protein-like 1-like
• UniProt Gene Name: GMCL1P1
• UniProt Synonym Gene Names: GCL; GMCL1L
• UniProt Entry Name: GMCLL_HUMAN

NCBI Description

This locus shares a high degree of identity with the multi-exon germ cell-less gene on chromosome 2. Despite its single-exon nature, this chromosome 5 locus contains an open reading frame that could putatively encode a full-length germ cell-less related protein. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport

By similarity. Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ref.3

Pathway: Protein modification; protein ubiquitination.

Subunit structure: Interacts with TMPO-Beta, TSG101 and TFDP2. Interacts with EMD

By similarity. Interacts with CUL3. Ref.3

Subcellular location: Nucleus matrix

By similarity.

Sequence similarities: Contains 1 BTB (POZ) domain.