Rabbit anti-Human, Mouse GMCL1 Polyclonal Antibody | anti-GMCL1 antibody

GMCL1 Antibody (Center)

Cat. Num. AAA9216192

• Gene Names: GMCL1; GCL; GCL1; BTBD13; SPATA29
• Reactivity: Human, Mouse
• Applications: Western Blot
• Synonyms: GMCL1; Polyclonal Antibody; GMCL1 Antibody (Center); Purified Rabbit Polyclonal Antibody (Pab); Germ cell-less protein-like 1; GCL; anti-GMCL1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This GMCL1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 281-315 amino acids from the Central region of human GMCL1.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 515

• Applicable Applications for anti-GMCL1 antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-GMCL1 Antibody (Center) at 1:2000 dilutionLane 1: 293T/17 whole cell lysateLane 2: HL-60 whole cell lysateLane 3: mouse testis lysateLane 4: MCF-7 whole cell lysateLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 59 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-GMCL1 antibody

Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).

Product Categories/Family for anti-GMCL1 antibody

Crown Antibodies; Cell Biology

References

Ota T.,et al.Nat. Genet. 36:40-45(2004). Holaska J.M.,et al.J. Biol. Chem. 278:6969-6975(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 30410765
• NCBI GeneID: 64395
• NCBI Accession #: NP_848526.1
• NCBI GenBank Nucleotide #: NM_178439.3
• UniProt Accession #: Q96IK5; Q9H826; Q9H8V7; Q9H927
• Molecular Weight: 58685
• NCBI Official Full Name: germ cell-less protein-like 1
• NCBI Official Synonym Full Names: germ cell-less, spermatogenesis associated 1
• NCBI Official Symbol: GMCL1
• NCBI Official Synonym Symbols: GCL; GCL1; BTBD13; SPATA29
• NCBI Protein Information: germ cell-less protein-like 1
• UniProt Protein Name: Germ cell-less protein-like 1
• Protein Family: Germ cell-less protein
• UniProt Gene Name: GMCL1
• UniProt Synonym Gene Names: GCL
• UniProt Entry Name: GMCL1_HUMAN

NCBI Description

This gene encodes a nuclear envelope protein that appears to be involved in spermatogenesis, either directly or by influencing genes that play a more direct role in the process. This multi-exon locus is the homolog of the mouse and drosophila germ cell-less gene but the human genome also contains a single-exon locus on chromosome 5 that contains an open reading frame capable of encoding a highly-related protein. [provided by RefSeq, Jul 2008]

Uniprot Description

GMCL1: Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport.

Chromosomal Location of Human Ortholog: 2p13.3

Cellular Component: nuclear matrix; nuclear envelope

Biological Process: regulation of transcription, DNA-dependent; multicellular organismal development; spermatogenesis; cell differentiation