Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Mouse Glypican 1 (GPC1) Polyclonal Antibody | anti-GPC1 antibody
Polyclonal Antibody to Glypican 1 (GPC1)
MGHHHHHHSGSEF- GNPKVNPH GSGPEEKRRR GKLALQEKPS TGTLEKLVSE AKAQLRDIQD FWISLPGTLC SEKMAMSPAS DDRCWNGISK GRYLPEVMGD GLANQINNPE VEVDITKPDM TIRQQIMQLK IMTNRLRGAY GGNDVDFQDA SDDGSGSGSG GGCPDDTCGR RVSKKSSSSR TPLTHALPGL SEQEGQKTSA ATCPEPHSFF LLFLV
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
NCBI and Uniprot Product Information
Uniprot Description
GPC1: Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Associates (via the heparan sulfate side chains) with fibrillar APP-beta amyloid peptides in primitive and classic amyloid plaques and may be involved in the deposition of these senile plaques in the Alzheimer disease (AD) brain. Misprocessing of GPC1 is found in fibroblasts of patients with Niemann-Pick Type C1 disease. This is due to the defective deaminative degradation of heparan sulfate chains. Belongs to the glypican family.
Protein type: Extracellular matrix; Membrane protein, GPI anchor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1|1 D
Cellular Component: cell soma; cytosol; endosome; extracellular matrix; extracellular region; membrane; membrane raft; nucleoplasm; plasma membrane; proteinaceous extracellular matrix
Molecular Function: copper ion binding; fibroblast growth factor binding; heparan sulfate proteoglycan binding; laminin binding
Biological Process: heparan sulfate proteoglycan catabolic process; myelin formation; negative regulation of fibroblast growth factor receptor signaling pathway; Schwann cell differentiation
Research Articles on GPC1
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Product Notes
The GPC1 gpc1 (Catalog #AAA2004153) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Glypican 1 (GPC1) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Glypican 1 (GPC1) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the GPC1 gpc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF- GNPKVNPH GSGPEEKRRR GKLALQEKPS TGTLEKLVSE AKAQLRDIQD FWISLPGTLC SEKMAMSPAS DDRCWNGISK GRYLPEVMGD GLANQINNPE VEVDITKPDM TIRQQIMQLK IMTNRLRGAY GGNDVDFQDA SDDGSGSGSG GGCPDDTCGR RVSKKSSSSR TPLTHALPGL SEQEGQKTSA ATCPEPHSFF LLFLV. It is sometimes possible for the material contained within the vial of "Glypican 1 (GPC1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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