Rabbit anti-Human GIGYF2 Polyclonal Antibody | anti-GIGYF2 antibody

GIGYF2 Rabbit Polyclonal

Cat. Num. AAA769686

• Gene Names: GIGYF2; GYF2; PERQ2; PERQ3; PARK11; TNRC15
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: GIGYF2; Polyclonal Antibody; GIGYF2 Rabbit Polyclonal; anti-GIGYF2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 1320

• Applicable Applications for anti-GIGYF2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: GRB10 interacting GYF protein 2
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using MBS769686 (GIGYF2 Antibody) at dilution of 1:50)

Western Blot (WB)

(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS769686 (GIGYF2 Antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 148922143
• NCBI GeneID: 26058
• Molecular Weight: 149,486 Da
• NCBI Official Full Name: GIGYF2 protein
• NCBI Official Synonym Full Names: GRB10 interacting GYF protein 2
• NCBI Official Symbol: GIGYF2
• NCBI Official Synonym Symbols: GYF2; PERQ2; PERQ3; PARK11; TNRC15
• NCBI Protein Information: PERQ amino acid-rich with GYF domain-containing protein 2
• UniProt Protein Name: PERQ amino acid-rich with GYF domain-containing protein 2
• Protein Family: PERQ amino acid-rich with GYF domain-containing protein
• UniProt Gene Name: GIGYF2
• UniProt Synonym Gene Names: KIAA0642; PERQ2; TNRC15
• UniProt Entry Name: PERQ2_HUMAN

NCBI Description

This gene contains CAG trinucleotide repeats and encodes a protein containing several stretches of polyglutamine residues. The encoded protein may be involved in the regulation of tyrosine kinase receptor signaling. This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11, and mutations in this gene were thought to be causative for this disease. However, more recent studies in different populations have been unable to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Uniprot Description

TNRC15 iso3: May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors. Defects in GIGYF2 are may be the cause of Parkinson disease type 11 (PARK11). A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. Belongs to the PERQ family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: cell-cell adherens junction; endoplasmic reticulum; endosome; Golgi apparatus; membrane; perikaryon; stress granule

Molecular Function: protein binding

Biological Process: insulin-like growth factor receptor signaling pathway; negative regulation of translation; posttranscriptional gene silencing

Disease: Parkinson Disease 11, Autosomal Dominant