Rabbit anti-Human GBP1 Polyclonal Antibody | anti-GBP1 antibody

GBP1 Rabbit Polyclonal

Cat. Num. AAA769605

• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: GBP1; Polyclonal Antibody; GBP1 Rabbit Polyclonal; anti-GBP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 592

• Applicable Applications for anti-GBP1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
• Immunogen: Guanylate binding protein 1, interferon-inducible, 67kDa
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human endometrial cancer using MBS769605 (GBP1 antibody) at dilution of 1:50)

Immunofluorescence (IF)

(Immunofluorescent analysis of MCF-7 cells, using GBP1 antibody MBS769605 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red) .)

Western Blot (WB)

(HUVEC cells were subjected to SDS PAGE followed by western blot with MBS769605 (GBP1 Antibody) at dilution of 1:1500)

NCBI and Uniprot Product Information

• NCBI GI #: 166706903
• NCBI GeneID: 2633
• NCBI Accession #: NP_002044.2
• NCBI GenBank Nucleotide #: NM_002053.2
• Molecular Weight: 67,931 Da
• NCBI Official Full Name: guanylate-binding protein 1
• NCBI Official Synonym Full Names: guanylate binding protein 1
• NCBI Official Symbol: GBP1
• NCBI Protein Information: guanylate-binding protein 1
• UniProt Protein Name: Guanylate-binding protein 1
• Protein Family: Guanylate-binding protein
• UniProt Gene Name: GBP1
• UniProt Synonym Gene Names: GBP-1; HuGBP-1
• UniProt Entry Name: GBP1_HUMAN

NCBI Description

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]

Uniprot Description

GBP1: a member of the family of large GTP-binding proteins (GBPs) that is inducible by interferon. Possesses a high GTP hydrolysis activity. GBPs are the most abundant cellular proteins expressed in response to interferon-gamma (IFN-gamma). IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) strongly induce the expression of GBP-1, -2, and -3.

Protein type: Hydrolase; Vesicle; Cell adhesion

Chromosomal Location of Human Ortholog: 1p22.2

Cellular Component: cytosol; extracellular region; Golgi membrane; plasma membrane

Molecular Function: actin binding; cytokine binding; enzyme binding; GTP binding; GTPase activity; Hsp90 protein binding; identical protein binding; protein binding; spectrin binding

Biological Process: defense response to virus; metabolic process; negative regulation of T cell receptor signaling pathway; regulation of calcium-mediated signaling