Rabbit anti-Human GBP1 Monoclonal Antibody | anti-GBP1 antibody

GBP1 Rabbit mAb

Cat. Num. AAA4753280

• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Immunocytochemistry, Immunofluorescence
• Purity: Affinity purified
• Synonyms: GBP1; Monoclonal Antibody; GBP1 Rabbit mAb; GTP-binding protein 1; anti-GBP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: 50nM Tris-Glycine (pH7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA

• Applicable Applications for anti-GBP1 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
• Application Notes: WB: 1:1000; IHC: 1:20; ICC/IF: 1:50
• Immunogen: A synthetic peptide of human GBP1
• Conjugation: Unconjugated
• Modification: Unmodification
• Preparation and Storage: Store at 4 degree C short term. Store at -20 degree C long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Western blot detection of GBP1 in HepG2,U251,HL-60,Lncap using GBP1 Rabbit mAb(1:1000 diluted))

NCBI and Uniprot Product Information

• NCBI GI #: 166706903
• NCBI GeneID: 2633
• NCBI Accession #: NP_002044.2
• NCBI GenBank Nucleotide #: NM_002053.2
• UniProt Accession #: P32455; Q5T8M1; D3DT26
• Molecular Weight: 67,931 Da
• NCBI Official Full Name: interferon-induced guanylate-binding protein 1
• NCBI Official Synonym Full Names: guanylate binding protein 1, interferon-inducible
• NCBI Official Symbol: GBP1
• NCBI Protein Information: interferon-induced guanylate-binding protein 1; GBP-1; huGBP-1; GTP-binding protein 1; guanine nucleotide-binding protein 1; guanylate binding protein 1, interferon-inducible, 67kDa
• UniProt Protein Name: Interferon-induced guanylate-binding protein 1
• Protein Family: Guanylate-binding protein
• UniProt Gene Name: GBP1
• UniProt Synonym Gene Names: GBP-1; HuGBP-1
• UniProt Entry Name: GBP1_HUMAN

NCBI Description

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]

Uniprot Description

GBP1: a member of the family of large GTP-binding proteins (GBPs) that is inducible by interferon. Possesses a high GTP hydrolysis activity. GBPs are the most abundant cellular proteins expressed in response to interferon-gamma (IFN-gamma). IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) strongly induce the expression of GBP-1, -2, and -3.

Protein type: Vesicle; Cell adhesion; Hydrolase

Chromosomal Location of Human Ortholog: 1p22.2

Cellular Component: Golgi membrane; extracellular region; cytosol

Molecular Function: GTPase activity; identical protein binding; GTP binding

Biological Process: metabolic process; cytokine and chemokine mediated signaling pathway; defense response to virus