Western Blot (WB)
(GAR1 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the GAR1 antibody detected the GAR1 protein (arrow).)
Rabbit GAR1 Polyclonal Antibody | anti-GAR1 antibody
GAR1 Antibody (Center)
Western Blot (WB)
(GAR1 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the GAR1 antibody detected the GAR1 protein (arrow).)
Western Blot (WB)
(GAR1 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the GAR1 antibody detected the GAR1 protein (arrow).)
nucleolar ribonucleoproteins) gene family. snoRNPs are involved in
various aspects of rRNA processing and modification and have been
classified into two families: C/D and H/ACA. The H/ACA snoRNPs also
include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP
proteins localize to the dense fibrillar components of nucleoli and
to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production
and rRNA pseudouridylation are impaired if any one of the four
proteins is depleted. These four H/ACA snoRNP proteins are also
components of the telomerase complex. The encoded protein of this
gene contains two glycine- and arginine-rich domains and is related
to Saccharomyces cerevisiae Gar1p. Two splice variants have been
found for this gene.
Hamma, T., et al. J. Biol. Chem. 285(2):805-809(2010)
Pigullo, S., et al. Pediatr Blood Cancer 52(3):376-378(2009)
Vasan, R.S., et al. BMC Med. Genet. 8 SUPPL 1, S2 (2007) :
Andersen, J.S., et al. Nature 433(7021):77-83(2005)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
NOLA1: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (psi) residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. Belongs to the GAR1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding; Nucleolus
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: Cajal body; nucleolus; nucleus
Molecular Function: cation channel activity
Biological Process: pseudouridine synthesis; rRNA processing; cation transport
Research Articles on GAR1
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Product Notes
The GAR1 gar1 (Catalog #AAA9205427) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 86-114. The GAR1 Antibody (Center) reacts with Human (Predicted Reactivity: Zebrafish, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's GAR1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the GAR1 gar1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GAR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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