Rabbit MAPKBP1 Polyclonal Antibody | anti-MAPKBP1 antibody

MAPKBP1 Polyclonal Antibody

Cat. Num. AAA8527400

• Gene Names: MAPKBP1; JNKBP1; NPHP20; JNKBP-1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Affinity purification
• Synonyms: MAPKBP1; Polyclonal Antibody; MAPKBP1 Polyclonal Antibody; JNKBP-1; MGC138851; MGC138852; anti-MAPKBP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Sequence Length: 1514

• Applicable Applications for anti-MAPKBP1 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:200-1:500; IHC: 1:50-1:100; IF: 1:20-1:50
• Immunogen: Fusion protein of human MAPKBP1
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Preparation and Storage: Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of mouse livertissue, using MAPKBP1antibody.)

Related Product Information for anti-MAPKBP1 antibody

MAP kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. MAPKBP-1 (mitogen-activated protein kinase binding protein 1), also known as JNKBP-1, is a 1, 514 amino acid protein that contains twelve WD repeats. Induced by TRAF2 (TNF receptor-associated factor 2) and Tak1 (TGF-beta-activated kinase 1), MAPKBP-1 is thought to act an adaptor protein for NFkappaB (nuclear factor kappa-B) activation. MAPKBP-1 interacts with JNK3 and may promote TRAF2 polyubiquitination. MAPKBP-1 exists as six alternatively spliced variants and is encoded by a gene located on human chromosome 15. Human chromosome 15 houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.

NCBI and Uniprot Product Information

• NCBI GI #: 190684677
• NCBI GeneID: 23005
• NCBI Accession #: NP_001122080.1
• NCBI GenBank Nucleotide #: NM_001128608.1
• UniProt Accession #: O60336; Q14CB5; Q14CD8; Q49AJ8; Q5W9G9; A6NM93; A8K8P9
• Molecular Weight: 109kDa; 164kDa
• NCBI Official Full Name: mitogen-activated protein kinase-binding protein 1 isoform b
• NCBI Official Synonym Full Names: mitogen-activated protein kinase binding protein 1
• NCBI Official Symbol: MAPKBP1
• NCBI Official Synonym Symbols: JNKBP1; NPHP20; JNKBP-1
• NCBI Protein Information: mitogen-activated protein kinase-binding protein 1
• UniProt Protein Name: Mitogen-activated protein kinase-binding protein 1
• Protein Family: Mitogen-activated protein kinase-binding protein
• UniProt Gene Name: MAPKBP1
• UniProt Synonym Gene Names: JNKBP1; KIAA0596; JNKBP-1

NCBI Description

This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017]

Uniprot Description

Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway ().