Rabbit anti-Human G6PC3 Polyclonal Antibody | anti-G6PC3 antibody

G6PC3 Rabbit Polyclonal

Cat. Num. AAA769500

• Gene Names: G6PC3; SCN4; UGRP
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: G6PC3; Polyclonal Antibody; G6PC3 Rabbit Polyclonal; anti-G6PC3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 195

• Applicable Applications for anti-G6PC3 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Immunogen: Glucose 6 phosphatase, catalytic, 3
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver tissue slide using MBS769500 (G6PC3 Antibody) at dilution of 1:200)

NCBI and Uniprot Product Information

• NCBI GI #: 985801711
• NCBI GeneID: 92579
• NCBI Accession #: NP_001306874.1
• NCBI GenBank Nucleotide #: NM_001319945.1
• Molecular Weight: 38,735 Da
• NCBI Official Full Name: glucose-6-phosphatase 3 isoform 4
• NCBI Official Synonym Full Names: glucose-6-phosphatase catalytic subunit 3
• NCBI Official Symbol: G6PC3
• NCBI Official Synonym Symbols: SCN4; UGRP
• NCBI Protein Information: glucose-6-phosphatase 3
• UniProt Protein Name: Glucose-6-phosphatase 3
• Protein Family: Glucose-6-phosphatase
• UniProt Gene Name: G6PC3
• UniProt Synonym Gene Names: UGRP; G-6-Pase 3; G6Pase 3; G6Pase-beta
• UniProt Entry Name: G6PC3_HUMAN

NCBI Description

This gene encodes the catalytic subunit of glucose-6-phosphatase (G6Pase). G6Pase is located in the endoplasmic reticulum (ER) and catalyzes the hydrolysis of glucose-6-phosphate to glucose and phosphate in the last step of the gluconeogenic and glycogenolytic pathways. Mutations in this gene result in autosomal recessive severe congenital neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Description

G6PC3: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function. Defects in G6PC3 are the cause of neutropenia severe congenital autosomal recessive type 4 (SCN4). Autosomal recessive SCN constitutes a primary immunodeficiency syndrome associated with increased apoptosis in myeloid cells. Individuals show a paucity of mature neutrophils in peripheral blood and bone marrow and develop life-threatening bacterial infections. SCN4 is a severe congenital neutropenia syndrome associated with cardiac and urogenital malformations. Defects in G6PC3 are the cause of Dursun syndrome (DURSS). A disease characterized by pulmonary arterial hypertension, cardiac abnormalities including secundum-type atrial septal defect, intermittent neutropenia, lymphopenia, monocytosis and anemia. Belongs to the glucose-6-phosphatase family.

Protein type: Transporter; Membrane protein, integral; EC 3.1.3.9; Phosphatase (non-protein); Transporter, SLC family; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; membrane

Molecular Function: glucose-6-phosphatase activity

Biological Process: dephosphorylation; gluconeogenesis; glucose 6-phosphate metabolic process; glucose transport; glucose-6-phosphate transport

Disease: Neutropenia, Severe Congenital, 4, Autosomal Recessive