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(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
TRIB3 recombinant protein
TRIB3 Protein
Applications
Western Blot
Synonyms
TRIB3; TRIB3 Protein; NIPK; SINK; SKIP3; TRB3; TRIB3 recombinant protein
Host
Sf9 insect cells
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Applicable Applications for TRIB3 recombinant protein
Western Blot (WB)
Tag
GST
Species
Human
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
SDS-Page
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
SDS-Page
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
Related Product Information for TRIB3 recombinant protein
Recombinant full-length human TRIB3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The TRIB3 gene accession number is NM_021158.
TRIB3 or tribbles homolog 3 protein encode one of three members of the Tribbles family that share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. TRIB3 is a negative regulator of NF-kappaB and can also sensitize cells to TNF-and TRAIL-induced apoptosis. TRIB3 can negatively regulate the cell survival serine-threonine kinase AKT1. TRIB3 modulation by H. pylori and/or its products may be an important mechanism of H. pylori-associated pathogenesis (1). TRIB3 is a p65-interacting negative regulator of NF-kappa-B-dependent transcription (2). TRIB3 is highly expressed in pancreas, peripheral blood leukocytes, and bone marrow.
TRIB3 or tribbles homolog 3 protein encode one of three members of the Tribbles family that share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. TRIB3 is a negative regulator of NF-kappaB and can also sensitize cells to TNF-and TRAIL-induced apoptosis. TRIB3 can negatively regulate the cell survival serine-threonine kinase AKT1. TRIB3 modulation by H. pylori and/or its products may be an important mechanism of H. pylori-associated pathogenesis (1). TRIB3 is a p65-interacting negative regulator of NF-kappa-B-dependent transcription (2). TRIB3 is highly expressed in pancreas, peripheral blood leukocytes, and bone marrow.
Product Categories/Family for TRIB3 recombinant protein
References
1. Qi, L.et.al: TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science 312: 1763-1766, 2006.
2. Wu, M. et.al: SINK is a p65-interacting negative regulator of NF-kappa-B-dependent transcription. J. Biol. Chem. 278: 27072-27079, 2003.
2. Wu, M. et.al: SINK is a p65-interacting negative regulator of NF-kappa-B-dependent transcription. J. Biol. Chem. 278: 27072-27079, 2003.
NCBI and Uniprot Product Information
Similar Products
Product Notes
The TRIB3 (Catalog #AAA517711) is a Recombinant Protein produced from Sf9 insect cells and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's TRIB3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the TRIB3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRIB3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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