Rabbit FRMPD2 Polyclonal Antibody | anti-FRMPD2 antibody

FRMPD2 Antibody

Cat. Num. AAA9402150

• Gene Names: FRMPD2; PDZK4; PDZD5C; PDZK5C
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: FRMPD2; Polyclonal Antibody; FRMPD2 Antibody; FERM and PDZ domain-containing 2; PDZD5C; PDZK5C; anti-FRMPD2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 1309

• Applicable Applications for anti-FRMPD2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 15 amino acid peptide from near the amino terminus of human FRMPD2.
• Target Name: FRMPD2
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of FRMPD2 in rat kidney tissue lysate with FRMPD2 antibody at (A) 1 and (B) 2 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of FRMPD2 in mouse kidney tissue with FRMPD2 antibody at 5 ug/mL.)

Related Product Information for anti-FRMPD2 antibody

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL. FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1. Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation. Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.

Product Categories/Family for anti-FRMPD2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 281604114
• NCBI GeneID: 143162
• NCBI Accession #: NP_001018081
• NCBI GenBank Nucleotide #: NM_001018071.3
• Molecular Weight: 28,774 Da
• NCBI Official Full Name: FERM and PDZ domain-containing protein 2 isoform 3
• NCBI Official Synonym Full Names: FERM and PDZ domain containing 2
• NCBI Official Symbol: FRMPD2
• NCBI Official Synonym Symbols: PDZK4; PDZD5C; PDZK5C
• NCBI Protein Information: FERM and PDZ domain-containing protein 2
• UniProt Protein Name: FERM and PDZ domain-containing protein 2
• Protein Family: FERM and PDZ domain-containing protein
• UniProt Gene Name: FRMPD2
• UniProt Synonym Gene Names: PDZD5C; PDZK4; PDZK5C
• UniProt Entry Name: FRPD2_HUMAN

NCBI Description

This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009]

Uniprot Description

FRMPD2: May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q11.22

Cellular Component: cytoskeleton; tight junction; basolateral plasma membrane; cytoplasm

Molecular Function: protein binding; phosphatidylinositol binding