Rabbit anti-Human FRAT2 Polyclonal Antibody | anti-FRAT2 antibody

FRAT2, CT (FRAT2, GSK-3-binding protein FRAT2, Frequently rearranged in advanced T-cell lymphomas 2) (MaxLight 405)

Cat. Num. AAA6300086

• Reactivity: Human
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: FRAT2; Polyclonal Antibody; CT (FRAT2; GSK-3-binding protein FRAT2; Frequently rearranged in advanced T-cell lymphomas 2) (MaxLight 405); Frequently rearranged in advanced T-cell lymphomas 2; anti-FRAT2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

• Applicable Applications for anti-FRAT2 antibody: Immunofluorescence (IF), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IF: 1:10-50; FLISA: 1:1,000; IHC: 1:10-50; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: FRAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-233 amino acids from the C-terminal region of human FRAT2.
• Conjugate: MaxLight405
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-FRAT2 antibody

The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.

Product Categories/Family for anti-FRAT2 antibody

Antibodies; Binding Proteins

References

Lee, D.Y., et al. Menopause 17(5):1064-1070(2010). Liu, G.P., et al. Neurobiol. Aging 29(9):1348-1358(2008). Stoothoff, W.H., et al. J. Biol. Chem. 280(1):270-276(2005). Deloukas, P., et al. Nature 429(6990):375-381(2004). Freemantle, S.J., et al. Gene 291 (1-2), 17-27 (2002).

NCBI and Uniprot Product Information

• NCBI GI #: 16507243
• NCBI GeneID: 23401
• NCBI Accession #: NP_036215.1
• NCBI GenBank Nucleotide #: NM_012083.2
• UniProt Accession #: O75474; Q5JTI0; Q8WUL9; Q9BYG2
• Molecular Weight: 24,051 Da
• NCBI Official Full Name: GSK-3-binding protein FRAT2
• NCBI Official Synonym Full Names: frequently rearranged in advanced T-cell lymphomas 2
• NCBI Official Symbol: FRAT2
• NCBI Protein Information: GSK-3-binding protein FRAT2
• UniProt Protein Name: GSK-3-binding protein FRAT2
• Protein Family: GSK-3-binding protein
• UniProt Gene Name: FRAT2
• UniProt Synonym Gene Names: FRAT-2
• UniProt Entry Name: FRAT2_HUMAN

NCBI Description

The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008]

Uniprot Description

FRAT2: Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. Belongs to the GSK-3-binding protein family.

Protein type: Cell development/differentiation

Chromosomal Location of Human Ortholog: 10q24.1

Cellular Component: cytosol

Biological Process: cell proliferation; Wnt receptor signaling pathway; multicellular organismal development