Rabbit anti-Human FOXRED2 Polyclonal Antibody | anti-FOXRED2 antibody

FOXRED2 Antibody

Cat. Num. AAA151568

• Gene Names: FOXRED2; ERFAD
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: FOXRED2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: FOXRED2; Polyclonal Antibody; FOXRED2 Antibody; ERFAD; FAD-dependent oxidoreductase domain-containing protein 2; Endoplasmic reticulum flavoprotein associated with degradation; FAD-dependent oxidoreductase domain containing 2; anti-FOXRED2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: FOXRED2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 684

• Applicable Applications for anti-FOXRED2 antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
• Application Notes: FOXRED2 antibody can be used for detection of FOXRED2 by Western blot at 1 mug/mL. Antibody can also be used for immunofluorescence starting at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: FOXRED2 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human FOXRED2.
• Buffer: FOXRED2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: FOXRED2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of FOXRED2 in human lung tissue lysate with FOXRED2 antibody at 1 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of FOXRED2 in human lung cells with FOXRED2 antibody at 20 μg/mL.)

Related Product Information for anti-FOXRED2 antibody

FOXRED2 Antibody: FOXRED2, also known as ERFAD, is an endoplasmic reticulum (ER) luminal flavoprotein which may function in ER associated degradation (ERAD). It has been proposed to bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. Upon knockdown of FOXRED2, the degradation of the ERAD model substrate ribophorin 332 is delayed, and the overall level of polyubiquitinated cellular proteins is decreased. Defects in the related protein FOXRED1 are a cause of mitochondrial complex I deficiency (MT-C1D), suggesting the FOXRED2 may also play a role in MT-C1D.

NCBI and Uniprot Product Information

• NCBI GI #: 156139139
• NCBI GeneID: 80020
• NCBI Accession #: NP_079231.4
• NCBI GenBank Nucleotide #: NM_024955.5
• UniProt Accession #: Q8IWF2; Q8N378; Q96BD1; Q9H5L5; Q9H6M8; B2RDI4
• Molecular Weight: 41,157 Da
• NCBI Official Full Name: FAD-dependent oxidoreductase domain-containing protein 2
• NCBI Official Synonym Full Names: FAD-dependent oxidoreductase domain containing 2
• NCBI Official Symbol: FOXRED2
• NCBI Official Synonym Symbols: ERFAD
• NCBI Protein Information: FAD-dependent oxidoreductase domain-containing protein 2; endoplasmic reticulum flavoprotein associated with degradation
• UniProt Protein Name: FAD-dependent oxidoreductase domain-containing protein 2
• Protein Family: FAD-dependent oxidoreductase domain-containing protein
• UniProt Gene Name: FOXRED2
• UniProt Synonym Gene Names: ERFAD
• UniProt Entry Name: FXRD2_HUMAN

Uniprot Description

FOXRED2: Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. Belongs to the FOXRED2 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 22q12.3

Cellular Component: endoplasmic reticulum lumen

Molecular Function: protein binding; FAD binding; oxidoreductase activity; glycoprotein binding

Biological Process: ER-associated protein catabolic process