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Immunohistochemistry (IHC) (Immunohistochemistry analysis of paraffin-embedded human brain tissue using FMN2 antibody.)

Rabbit anti-Human, Mouse FMN2 Polyclonal Antibody | anti-FMN2 antibody

FMN2 Antibody

Reactivity
Human, Mouse
Applications
Immunohistochemistry
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
FMN2; Polyclonal Antibody; FMN2 Antibody; Formin-2; anti-FMN2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total FMN2 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
1726
Applicable Applications for anti-FMN2 antibody
Immunohistochemistry (IHC)
Application Notes
Immunohistochemistry: 1:50~1:100
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from internal of human FMN2.
Target Name
FMN2
Preparation and Storage
Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human brain tissue using FMN2 antibody.)

Immunohistochemistry (IHC) (Immunohistochemistry analysis of paraffin-embedded human brain tissue using FMN2 antibody.)
Related Product Information for anti-FMN2 antibody
Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis By similarity. Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Protects cells against apoptosis by protecting CDKN1A against degradation.toki Y., Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.Leader B., " Mech. Dev. 93:221-231(2000).Matsuoka S., Science 316:1160-1166(2007).
Product Categories/Family for anti-FMN2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
36,871 Da
NCBI Official Full Name
formin-2 isoform 1
NCBI Official Synonym Full Names
formin 2
NCBI Official Symbol
FMN2
NCBI Protein Information
formin-2
UniProt Protein Name
Formin-2
Protein Family
UniProt Gene Name
FMN2
UniProt Entry Name
FMN2_HUMAN

NCBI Description

This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. Mutations in this gene have been associated with mental retardation autosomal recessive 47 (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]

Uniprot Description

FMN2: Belongs to the formin homology family. Cappuccino subfamily

Protein type: Nucleolus; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: endoplasmic reticulum membrane; microvillus; cytoplasmic vesicle membrane; perinuclear region of cytoplasm; plasma membrane; nucleolus; spindle; cell cortex; cytosol; actin cytoskeleton

Molecular Function: actin binding

Biological Process: homologous chromosome movement towards spindle pole during meiosis I; oogenesis; vesicle-mediated transport; establishment of meiotic spindle localization; protein transport; intracellular transport; multicellular organismal development; polar body extrusion after meiotic divisions; negative regulation of protein catabolic process; response to DNA damage stimulus; negative regulation of apoptosis

Disease: Mental Retardation, Autosomal Recessive 47

Research Articles on FMN2

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Product Notes

The FMN2 fmn2 (Catalog #AAA9403047) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FMN2 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's FMN2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:50~1:100. Researchers should empirically determine the suitability of the FMN2 fmn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FMN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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