Western Blot (WB)
(Western blot analysis of extracts from SKOV3 cells, using FMN2 Antibody. The lane on the left was treated with blocking peptide.)
Rabbit FMN2 Polyclonal Antibody | anti-FMN2 antibody
FMN2 Antibody
Predicted: Rabbit
Predicted: Rabbit
Western Blot (WB)
(Western blot analysis of extracts from SKOV3 cells, using FMN2 Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from SKOV3 cells, using FMN2 Antibody. The lane on the left was treated with blocking peptide.)
Subunit Structure: Interacts with SPIRE1. Binds actin. Interacts with CDKN1A.
Similarity: Belongs to the formin homology family. Cappuccino subfamily.
NCBI and Uniprot Product Information
Predicted: 181 kDa
NCBI Description
This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. This protein mediates the formation of an actin mesh that positions the spindle during oogenesis and also regulates the formation of actin filaments in the nucleus. This protein also forms a perinuclear actin/focal-adhesion system that regulates the shape and position of the nucleus during cell migration. Mutations in this gene have been associated with infertility and also with an autosomal recessive form of intellectual disability (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2017]
Uniprot Description
FMN2: Belongs to the formin homology family. Cappuccino subfamily
Protein type: Motility/polarity/chemotaxis; Nucleolus
Chromosomal Location of Human Ortholog: 1q43
Cellular Component: endoplasmic reticulum membrane; microvillus; cytoplasmic vesicle membrane; perinuclear region of cytoplasm; nucleolus; plasma membrane; spindle; cell cortex; cytosol; actin cytoskeleton
Molecular Function: actin binding
Biological Process: homologous chromosome movement towards spindle pole during meiosis I; vesicle-mediated transport; oogenesis; establishment of meiotic spindle localization; protein transport; intracellular transport; multicellular organismal development; polar body extrusion after meiotic divisions; negative regulation of protein catabolic process; response to DNA damage stimulus; negative regulation of apoptosis
Disease: Mental Retardation, Autosomal Recessive 47
Research Articles on FMN2
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Product Notes
The FMN2 fmn2 (Catalog #AAA9611768) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FMN2 Antibody reacts with Human, Mouse Predicted: Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's FMN2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the FMN2 fmn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FMN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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