Rabbit FLG2 Polyclonal Antibody | anti-FLG2 antibody

FLG2 Antibody

Cat. Num. AAA9629563

• Gene Names: FLG2; IFPS
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: FLG2; Polyclonal Antibody; FLG2 Antibody; FILA2_HUMAN; Filaggrin-2; FLG-2; Ifapsoriasin; Intermediate filament-associated and psoriasis-susceptibility protein; anti-FLG2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: FLG2 Antibody detects endogenous levels of total FLG2.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-FLG2 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: Belongs to the S100-fused protein family. In the N-terminal section; belongs to the S-100 family.
• Post Translational Modifications: Deiminated by PADI1, PADI2 or PADI3 in vitro. The deiminated form is degraded by calpain-1/CAPN1 more quickly and into shorter peptides than the intact protein.May be processed by calpain-1/CAPN1 in the uppermost epidermal layers.
• Tissue Specificity: Expressed in skin, thymus, stomach and placenta, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, adrenal gland, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea. Weakly expressed in esophagus, tonsils and testis (at protein level). In the skin, strongly expressed in the upper stratum granulosum and lower stratum corneum, but not detected in the upper stratum corneum (at protein level). In scalp hair follicles, mainly restricted within the granular and cornified cells surrounding the infundibular outer root sheath, with weak expression in central and proximal outer root sheath (at protein level). Tends to be down-regulated in sporiatic lesions compared to non-lesional skin inthe same patients.
• Function: Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis.
• Note: In the stratum corneum of the epidermis, dispersed diffusely throughout the cytoplasm, while in the stratum granulosum, localized within keratohyalin granules (PubMed:19384417) (PubMed:21531719). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-FLG2 antibody

Cytoplasm; Cytoplasmic granule; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 62122917
• NCBI GeneID: 388698
• NCBI Accession #: NP_001014364.1
• NCBI GenBank Nucleotide #: NM_001014342.2
• UniProt Accession #: Q5D862; Q9H4U1
• Molecular Weight: 248,073 Da
• NCBI Official Full Name: filaggrin-2
• NCBI Official Synonym Full Names: filaggrin family member 2
• NCBI Official Symbol: FLG2
• NCBI Official Synonym Symbols: IFPS
• NCBI Protein Information: filaggrin-2
• UniProt Protein Name: Filaggrin-2
• Protein Family: Filaggrin
• UniProt Gene Name: FLG2
• UniProt Synonym Gene Names: IFPS; FLG-2; Ifapsoriasin

NCBI Description

The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa. [provided by RefSeq, Dec 2015]