Western Blot (WB)
(Western Blot: Detection of LIMP II (~85kD) in various samples using MBS611922. ECL 40 minute exposure. Lane 1: Rat cardiac fibroblasts (RCF) Lane 2: 3T3 mouse fibroblasts Lane 3: Long hond canine lung lysate Lane 4: RCF treated with angiotensin II Lane 5: RCF treated with H2O2 Lane 6: HEPG2 human liver lysate)
Rabbit LIMPII Polyclonal Antibody | anti-SCARB2 antibody
LIMPII (Lysosomal Integral Membrane Protein II, 85kD Lysosomal Membrane Sialoglycoprotein, 85kD Lysosomal Sialoglycoprotein Scavenger Receptor Class B Member 2, CD36 Antigen (Collagen Type I Receptor Thrombospondin Receptor)-like 2, Lysosome Membrane Prot
Serum
Serum
Dilution: Western Blot: 1:1000
Immunoprecipitation: 1:100
Immunoflourescence: 1:50-1:250
Immunohistochemistry: 1:200
Immunocytochemistry: 1:250
Western Blot (WB)
(Western Blot: Detection of LIMP II (~85kD) in various samples using MBS611922. ECL 40 minute exposure. Lane 1: Rat cardiac fibroblasts (RCF) Lane 2: 3T3 mouse fibroblasts Lane 3: Long hond canine lung lysate Lane 4: RCF treated with angiotensin II Lane 5: RCF treated with H2O2 Lane 6: HEPG2 human liver lysate)
Western Blot (WB)
(Western Blot: Detection of LIMP II (~85kD) in various samples using MBS611922. ECL 40 minute exposure. Lane 1: Rat cardiac fibroblasts (RCF) Lane 2: 3T3 mouse fibroblasts Lane 3: Long hond canine lung lysate Lane 4: RCF treated with angiotensin II Lane 5: RCF treated with H2O2 Lane 6: HEPG2 human liver lysate)
Testing Data
(Staining of LIMPII using MBS611922 in rat infarctzone tissue with a DAB detection system.)
Testing Data
(Staining of LIMPII using MBS611922 in rat infarctzone tissue with a DAB detection system.)
Testing Data
(Detection of LIMPII (Green) in Hela cells using MBS611922. Nuclei (Blue) are counterstained using Hoechst 33258.)
Testing Data
(Detection of LIMPII (Green) in Hela cells using MBS611922. Nuclei (Blue) are counterstained using Hoechst 33258.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Uniprot Description
SCARB2: Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. Defects in SCARB2 are the cause of progressive myoclonic epilepsy type 4 with or without renal failure (EPM4). An autosomal recessive progressive myoclonic epilepsy associated with renal failure in some cases. Cognitive function is preserved. Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles. Cognitive function is preserved. Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease. Belongs to the CD36 family.
Protein type: Receptor, misc.; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q21.1
Cellular Component: lysosomal lumen; focal adhesion; membrane; lysosomal membrane; integral to membrane
Molecular Function: protein binding; enzyme binding; receptor activity
Biological Process: protein targeting to lysosome; cell adhesion
Disease: Epilepsy, Progressive Myoclonic 4, With Or Without Renal Failure
Research Articles on SCARB2
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Product Notes
The SCARB2 scarb2 (Catalog #AAA611922) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LIMPII (Lysosomal Integral Membrane Protein II, 85kD Lysosomal Membrane Sialoglycoprotein, 85kD Lysosomal Sialoglycoprotein Scavenger Receptor Class B Member 2, CD36 Antigen (Collagen Type I Receptor Thrombospondin Receptor)-like 2, Lysosome Membrane Prot reacts with Canine, Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's LIMPII can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF). Suitable for use in Western Blot, Immunoprecipitation, Immunoflourescence, Immunohistochemistry and Immunocytochemistry. Dilution: Western Blot: 1:1000 Immunoprecipitation: 1:100 Immunoflourescence: 1:50-1:250 Immunohistochemistry: 1:200 Immunocytochemistry: 1:250. Researchers should empirically determine the suitability of the SCARB2 scarb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LIMPII, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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