Mouse anti-Human FKBP8 Polyclonal Antibody | anti-FKBP8 antibody

FKBP8 (FKBP38, Peptidyl-prolyl Cis-trans Isomerase FKBP8, 38kD FK506-binding Protein, 38 kDa FKBP, FKBP-38, hFKBP38, FK506-binding Protein 8, FKBP-8, FKBPR38, Rotamase)

Cat. Num. AAA649358

• Gene Names: FKBP8; FKBP38; FKBPr38
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: FKBP8; Polyclonal Antibody; FKBP8 (FKBP38; Peptidyl-prolyl Cis-trans Isomerase FKBP8; 38kD FK506-binding Protein; 38 kDa FKBP; FKBP-38; hFKBP38; FK506-binding Protein 8; FKBP-8; FKBPR38; Rotamase); Anti -FKBP8 (FKBP38; anti-FKBP8 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FKBP8.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MASCAEPSEPSAPLPAGVPPLEDFEVLDGVEDAEGEEEEEEEEEEEDDLSELPPLEDMGQPPAEEAEQPGALAREFLAAMEPEPAPAPAPEEWLDILGNGLLRKKTLVPGPPGSSRPVKGQVVTVHLQTSLENGTRVQEEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYGPQGSRSPYIPPHAALCLEVTLKTAVDGPDLEMLTGQERVALANRKRECGNAHYQRADFVLAANSYDLAIKAITSSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQRSTETALYRKMLGNPSRLPAKCPGKGAWSIPWKWLFGATAVALGGVALSVVIAARN

• Applicable Applications for anti-FKBP8 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human FKBP8, aa1-413 (NP_036313.3).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of FKBP8 expression in transfected 293T cell line by FKBP8 polyclonal antibody. Lane 1: FKBP8 transfected lysate (45.43kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-FKBP8 antibody

FK506-binding protein 38 (FKBP38), a member of the immunophilin family, has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBK38 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes.

Product Categories/Family for anti-FKBP8 antibody

Antibodies; Abs to Enzymes; Isomerase

NCBI and Uniprot Product Information

• NCBI GI #: 35384711
• NCBI GeneID: 23770
• UniProt Accession #: Q14318; Q53GU3; Q7Z349; Q86YK6; C8C9T5
• Molecular Weight: 44,562 Da
• NCBI Official Full Name: FKBP8
• NCBI Official Synonym Full Names: FK506 binding protein 8, 38kDa
• NCBI Official Symbol: FKBP8
• NCBI Official Synonym Symbols: FKBP38; FKBPr38
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase FKBP8; FKBP-8; FKBP-38; hFKBP38; rotamase; 38 kDa FKBP; PPIase FKBP8; 38 kDa FK506-binding protein; FK506-binding protein 8 (38kD)
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP8
• Protein Family: Peptidyl-prolyl cis-trans isomerase
• UniProt Gene Name: FKBP8
• UniProt Synonym Gene Names: FKBP38; PPIase FKBP8; 38 kDa FKBP; FKBP-38; hFKBP38; FKBP-8
• UniProt Entry Name: FKBP8_HUMAN

NCBI Description

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Ref.1 Ref.10 Ref.12

Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0). Ref.11

Cofactor: Calcium. Ref.11

Subunit structure: Homomultimers or heteromultimers

Potential. Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCL2L1/BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation. Ref.1 Ref.3 Ref.12 Ref.13 Ref.15 Ref.16 Ref.17

Subcellular location: Isoform 1: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side Ref.1 Ref.3 Ref.10. Isoform 3: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side Ref.1 Ref.3 Ref.10.

Tissue specificity: Widely expressed. Highest levels seen in the brain. Highly abundant in the retina. Ref.3

Miscellaneous: Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form.

Sequence similarities: Contains 1 PPIase FKBP-type domain.Contains 3 TPR repeats.

Caution: It is uncertain whether Met-1 or Met-58 is the initiator.

Sequence caution: The sequence AAB00102.1 differs from that shown. Reason: The first part of the cDNA maps to the same locus, but in opposite orientation.The sequence AAH09966.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAD98028.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.