Western Blot (WB)
(Western Blot: Sample: Mouse Placenta lysate; Primary Ab: 3ug/ml Rabbit Anti-Mouse FKBP8 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Rabbit anti-Mouse FK506 Binding Protein 8 (FKBP8) Polyclonal Antibody | anti-FKBP8 antibody
Polyclonal Antibody to FK506 Binding Protein 8 (FKBP8)
MGHHHHHHSG SEF- G QVVTVHLQMS LENGTRVQEE PELAFTLGDC DVIQALDLSV PLMDVGETAM VTADSKYCYG PQGSRSPYIP PHAALCLEVT LKTAEDGPDL EMLSGQERVA LANRKRECGN AHYQRADFVL AANSYDLAIK AITSNTKVDM TCEEEEELLQ LKVKCLNNLA ASQLKLDHYR AALRSCSQVL EHQPDNIKAL FRKGKVLAQQ GEYSEAIPIL RAALKLEPS
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Mouse Placenta lysate; Primary Ab: 3ug/ml Rabbit Anti-Mouse FKBP8 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Mouse Placenta lysate; Primary Ab: 3ug/ml Rabbit Anti-Mouse FKBP8 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Lung Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Lung Tissue))
NCBI and Uniprot Product Information
Uniprot Description
FKBP8: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Chaperone; EC 5.2.1.8; Isomerase; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 8|8 B3.3
Cellular Component: cytosol; endoplasmic reticulum; integral component of endoplasmic reticulum membrane; integral component of membrane; membrane; mitochondrial envelope; mitochondrion; protein complex
Molecular Function: FK506 binding; identical protein binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity
Biological Process: apoptosis; camera-type eye development; cell fate specification; dorsal/ventral neural tube patterning; dorsal/ventral pattern formation; multicellular organism growth; negative regulation of apoptosis; negative regulation of protein phosphorylation; neural tube development; positive regulation of BMP signaling pathway; regulation of BMP signaling pathway; regulation of gene expression; smoothened signaling pathway
Research Articles on FKBP8
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Product Notes
The FKBP8 fkbp8 (Catalog #AAA2017746) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to FK506 Binding Protein 8 (FKBP8) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's FK506 Binding Protein 8 (FKBP8) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the FKBP8 fkbp8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF- G QVVTVHLQMS LENGTRVQEE PELAFTLGDC DVIQALDLSV PLMDVGETAM VTADSKYCYG PQGSRSPYIP PHAALCLEVT LKTAEDGPDL EMLSGQERVA LANRKRECGN AHYQRADFVL AANSYDLAIK AITSNTKVDM TCEEEEELLQ LKVKCLNNLA ASQLKLDHYR AALRSCSQVL EHQPDNIKAL FRKGKVLAQQ GEYSEAIPIL RAALKLEPS. It is sometimes possible for the material contained within the vial of "FK506 Binding Protein 8 (FKBP8), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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