Rabbit anti-Human, Mouse FKBP10 Polyclonal Antibody | anti-FKBP10 antibody

FKBP10 Polyclonal Antibody

Cat. Num. AAA9431727

• Gene Names: FKBP10; OI6; OI11; FKBP65; PPIASE; hFKBP65
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity purification
• Synonyms: FKBP10; Polyclonal Antibody; FKBP10 Polyclonal Antibody; BRKS1; FKBP65; OI11; OI6; PPIASE; hFKBP65; FK506 binding protein 10; anti-FKBP10 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 50% glycerol, pH7.4

• Applicable Applications for anti-FKBP10 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: Recombinant fusion protein of human FKBP10 (NP_068758.3).
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using FKBP10 antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver cancer using FKBP10 antibody.)

Related Product Information for anti-FKBP10 antibody

The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.

Product Categories/Family for anti-FKBP10 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 192448443
• NCBI GeneID: 60681
• NCBI Accession #: NP_068758.3
• NCBI GenBank Nucleotide #: NM_021939.3
• UniProt Accession #: Q96AY3; Q7Z3R4; Q9H3N3; Q9H6N5; Q9UF89
• Molecular Weight: 64,245 Da
• NCBI Official Full Name: peptidyl-prolyl cis-trans isomerase FKBP10
• NCBI Official Synonym Full Names: FK506 binding protein 10, 65 kDa
• NCBI Official Symbol: FKBP10
• NCBI Official Synonym Symbols: OI6; OI11; FKBP65; PPIASE; hFKBP65
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase FKBP10; FKBP-10; FKBP-65; rotamase; 65 kDa FKBP; PPIase FKBP10; immunophilin FKBP65; FK506-binding protein 10; 65 kDa FK506-binding protein
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP10
• Protein Family: Peptidyl-prolyl cis-trans isomerase
• UniProt Gene Name: FKBP10
• UniProt Synonym Gene Names: FKBP65; PSEC0056; PPIase FKBP10; 65 kDa FKBP; FKBP-65; FKBP-10
• UniProt Entry Name: FKB10_HUMAN

NCBI Description

The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]

Uniprot Description

FKBP10: PPIases accelerate the folding of proteins during protein synthesis. Defects in FKBP10 are the cause of osteogenesis imperfecta type 6 (OI6). OI6 is a moderate to severe, autosomal recessive form of osteogenesis imperfecta characterized by increased serum alkaline phosphatase levels and bone histology exhibiting a fish scale-like lamellar pattern. Osteogenesis imperfecta defines a group of connective tissue disorders characterized by bone fragility and low bone mass.

Protein type: EC 5.2.1.8; Isomerase

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen

Molecular Function: peptidyl-prolyl cis-trans isomerase activity; FK506 binding; calcium ion binding

Biological Process: protein peptidyl-prolyl isomerization

Disease: Osteogenesis Imperfecta, Type Xi; Bruck Syndrome 1