Rabbit anti-Human FGF5 Polyclonal Antibody | anti-FGF5 antibody

Anti-FGF5 Antibody, Rabbit Polyclonal

Cat. Num. AAA8100794

• Gene Names: FGF5; HBGF-5; TCMGLY; Smag-82
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: FGF5; Polyclonal Antibody; Anti-FGF5 Antibody; Rabbit Polyclonal; FGF5 Antibody; Rabbit PAb; Antigen Affinity Purified; fibroblast growth factor 5; Anti-HBGF-5 Antibody; Anti-Smag-82 Antibody; Anti-TCMGLY Antibody; anti-FGF5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human FGF5
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-FGF5 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:200-1:1000
• Immunogen: A synthetic peptide corresponding to the C-terminus of the Human FGF5
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human FGF5, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human FGF5 in human kidney with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-FGF5 antibody

Fibroblast growth factor 5 (FGF5) is a secreted signaling protein. FGF5 is expressed in the mesenchyme and skeletal muscle of developing and adult mouse limbs. FGF5 acts as a mitogen to stimulate the proliferation of mesenchymal fibroblasts that contribute to the formation of connective tissues such as the perichondrium, and inhibits the development of differentiated skeletal muscle. Fibroblast growth factor 5 (FGF5) regulates hair length in humans and a variety of other animals. Human aortic endothelial cells (HAECs) have greater angiogenic potential through FGF2 and FGF5 upregulation and could be a compatible endothelial cell type to achieve robust angiogenesis.

Product Categories/Family for anti-FGF5 antibody

Early Mesodermal Lineage Markers

NCBI and Uniprot Product Information

• NCBI GI #: 73486655
• NCBI GeneID: 2250
• NCBI Accession #: NP_004455.2
• NCBI GenBank Nucleotide #: NM_004464.3
• UniProt Accession #: P12034; O75846; Q3Y8M3; Q8NF90; B2R554
• Molecular Weight: 13,006 Da
• NCBI Official Full Name: fibroblast growth factor 5 isoform 1
• NCBI Official Synonym Full Names: fibroblast growth factor 5
• NCBI Official Symbol: FGF5
• NCBI Official Synonym Symbols: HBGF-5; TCMGLY; Smag-82
• NCBI Protein Information: fibroblast growth factor 5
• UniProt Protein Name: Fibroblast growth factor 5
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF5
• UniProt Synonym Gene Names: FGF-5; HBGF-5

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

FGF5: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Oncoprotein; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21.21

Cellular Component: extracellular region; extracellular space

Molecular Function: 1-phosphatidylinositol-3-kinase activity; fibroblast growth factor receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: cell proliferation; cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; nervous system development; phosphoinositide-mediated signaling; positive regulation of cell proliferation; regulation of phosphoinositide 3-kinase cascade

Disease: Trichomegaly