Rabbit anti-Human FEZ2 Polyclonal Antibody | anti-FEZ2 antibody

FEZ2, NT (FEZ2, Fasciculation and elongation protein zeta-2, Zygin II, Zygin-2) (APC)

Cat. Num. AAA6298847

• Gene Names: FEZ2; HUM3CL
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: FEZ2; Polyclonal Antibody; NT (FEZ2; Fasciculation and elongation protein zeta-2; Zygin II; Zygin-2) (APC); Zygin-2; anti-FEZ2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-FEZ2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: FEZ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human FEZ2.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(FEZ2 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the FEZ2 antibody detected the FEZ2 protein (arrow).)

Related Product Information for anti-FEZ2 antibody

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin.

Product Categories/Family for anti-FEZ2 antibody

Antibodies; Proteins

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010). Assmann, E.M., et al. J. Biol. Chem. 281(15):9869-9881(2006). Hillier, L.W., et al. Nature 434(7034):724-731(2005). Fujita, T., et al. Biochem. Biophys. Res. Commun. 313(3):738-744(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 110349754
• NCBI GeneID: 9637
• NCBI Accession #: NP_005093.2
• NCBI GenBank Nucleotide #: NM_005102.2
• UniProt Accession #: Q9UHY8; Q5EBN3; Q76LN0; Q99690
• Molecular Weight: 42,613 Da
• NCBI Official Full Name: fasciculation and elongation protein zeta-2 isoform 1
• NCBI Official Synonym Full Names: fasciculation and elongation protein zeta 2 (zygin II)
• NCBI Official Symbol: FEZ2
• NCBI Official Synonym Symbols: HUM3CL
• NCBI Protein Information: fasciculation and elongation protein zeta-2; zygin 2; zygin-2; zygin II; pre-T/NK cell associated protein (3Cl)
• UniProt Protein Name: Fasciculation and elongation protein zeta-2
• Protein Family: Fasciculation and elongation protein
• UniProt Gene Name: FEZ2
• UniProt Entry Name: FEZ2_HUMAN

NCBI Description

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]

Uniprot Description

FEZ2: Involved in axonal outgrowth and fasciculation. Belongs to the zygin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 2p21

Molecular Function: protein binding

Biological Process: axon guidance; nervous system development; signal transduction