Western Blot (WB)
(Western blot detection of FES in Raji cell lysates using FES Rabbit pAb(1:1000 diluted). Predicted band size:94KDa. Observed band size:94KDa.)
Rabbit anti-Human FES Polyclonal Antibody | anti-FES antibody
FES Rabbit pAb
ICC/IF: 1:20-1:50
FC/FACS: 1:20-1:100
IP: 1:20-1:50
Western Blot (WB)
(Western blot detection of FES in Raji cell lysates using FES Rabbit pAb(1:1000 diluted). Predicted band size:94KDa. Observed band size:94KDa.)
Western Blot (WB)
(Western blot detection of FES in Raji cell lysates using FES Rabbit pAb(1:1000 diluted). Predicted band size:94KDa. Observed band size:94KDa.)
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]
Uniprot Description
Fes: a non-receptor tyrosine kinase of the Fer family. Appears to be involved in normal hematopoiesis as well as the development of acute promyelocytic leukemia. Contains one SH2 and one FCH domain. Four LOF point mutations seen in colorectal cancer. Orthologous to v-fes from feline leukemia virus and v-fps from avian transforming virus. Mutant forms are angiogenic. Promotes survival during differentiation, and may act both to promote and inhibit tumors. May be disrupted in the t(15q+;17q-) found in acute promyelocytic leukemia, but the breakpoint does not occur within the gene.
Protein type: Oncoprotein; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Tumor suppressor; TK group; Fer family
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: microtubule cytoskeleton; Golgi apparatus; extrinsic to internal side of plasma membrane; focal adhesion; cytoplasm; cytoplasmic membrane-bound vesicle; cytoplasmic vesicle; cytosol
Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; phosphoinositide binding; ATP binding
Biological Process: regulation of cell adhesion; epidermal growth factor receptor signaling pathway; regulation of mast cell degranulation; axon guidance; cell migration; peptidyl-tyrosine phosphorylation; positive regulation of myeloid cell differentiation; multicellular organismal development; protein amino acid autophosphorylation; positive regulation of microtubule polymerization; chemotaxis; protein amino acid phosphorylation; regulation of cell proliferation; cell proliferation; regulation of cell shape; regulation of cell differentiation; innate immune response
Research Articles on FES
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Product Notes
The FES fes (Catalog #AAA4751962) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FES Rabbit pAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FES can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), Immunoprecipitation (IP). WB: 1:1000-1:5000 ICC/IF: 1:20-1:50 FC/FACS: 1:20-1:100 IP: 1:20-1:50. Researchers should empirically determine the suitability of the FES fes for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FES, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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