Rabbit anti-Mouse FABP2/I-FABP Polyclonal Antibody | anti-FABP2/I-FABP antibody

Anti-FABP2/I-FABP Antibody

Cat. Num. AAA1752486

• Gene Names: Fabp2; Fabpi; I-FABP
• Reactivity: Mouse
• Applications: ELISA
• Purity: Immunogen Affinity Purified
• Synonyms: FABP2/I-FABP; Polyclonal Antibody; Anti-FABP2/I-FABP Antibody; Fatty acid-binding protein; intestinal; fatty acid binding protein 2; Fatty acid-binding protein 2; Intestinal-type fatty acid-binding protein; I-FABP; Fabp2; Fabpi; anti-FABP2/I-FABP antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: No cross reactivity with other proteins.
• Purity/Purification: Immunogen Affinity Purified
• Form/Format: Lyophilized
• Sequence Length: 132

• Applicable Applications for anti-FABP2/I-FABP antibody: ELISA Capture (EIA)
• Application Notes: ELISA (Cap): 2-8ug/ml
• Immunogen: E Coli-derived mouse FABP2/I-FABP recombinant protein (Position: A2-E132).
• Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500mug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Related Product Information for anti-FABP2/I-FABP antibody

Description: Rabbit IgG polyclonal antibody for FABP2/I-FABP detection. Tested with ELISA(Cap) in Mouse.

Background: FABP 2, Fatty acid-binding protein 2, is a protein that in humans is encoded by the FABP2 gene. Using a human cDNA probe, the gene is assigned to chromosome 4 in somatic cell hybrids. FABP 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. The FABPs belong to a multigene family with nearly twenty identified members. And FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. Also, they may be responsible in the modulation of cell growth and proliferation.

References

1. Baier, L. J., Sacchettini, J. C., Knowler, W. C., Eads, J., Paolisso, G., Tataranni, P. A., Mochizuki, H., Bennett, P. H., Bogardus, C., Prochazka, M.An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.J. Clin. Invest. 95: 1281-1287, 1995. 2. Georgopoulos, A., Aras, O., Tsai, M. Y.Codon-54 polymorphism of the fatty acid-binding protein 2 gene is associated with elevation of fasting and postprandial triglyceride in type 2 diabetes.J. Clin. Endocr. Metab. 85: 3155-3160, 2000. 3. Sparkes, R. S., Mohandas, T., Heinzmann, C., Gordon, J. I., Klisak, I., Zollman, S., Sweetser, D. A., Ragunathan, L., Winokur, S., Lusis, A. J.Human fatty acid binding protein assignments intestinal to 4q28-4q31 and liver to 2p11. (Abstract)Cytogenet. Cell Genet. 46: 697 only, 1987.

NCBI and Uniprot Product Information

• NCBI GI #: 6679737
• NCBI GeneID: 14079
• NCBI Accession #: NP_032006.1
• NCBI GenBank Nucleotide #: NP_032006.1
• UniProt Accession #: P55050
• NCBI Official Full Name: fatty acid-binding protein, intestinal
• NCBI Official Synonym Full Names: fatty acid binding protein 2, intestinal
• NCBI Official Symbol: Fabp2
• NCBI Official Synonym Symbols: Fabpi; I-FABP
• NCBI Protein Information: fatty acid-binding protein, intestinal
• UniProt Protein Name: Fatty acid-binding protein, intestinal
• UniProt Gene Name: Fabp2
• UniProt Synonym Gene Names: Fabpi; I-FABP

NCBI Description

The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. This protein functions within enterocytes, possibly to sense lipids as part of energy homeostasis. In humans polymorphisms are associated with increased fat oxidation and insulin resistance. In mice deficiency of this gene alters body weight in a gender-specific manner and causes hyperinsulinemia. [provided by RefSeq, Jan 2013]

Uniprot Description

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.