Rabbit anti-Human ERLIN1 Polyclonal Antibody | anti-ERLIN1 antibody

ERLIN1, ID (ERLIN1, C10orf69, KE04, KEO4, SPFH1, Erlin-1, Endoplasmic reticulum lipid raft-associated protein 1, Protein KE04, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1) (MaxLight 490)

Cat. Num. AAA6296553

• Gene Names: ERLIN1; KE04; KEO4; SPFH1; SPG62; Erlin-1; C10orf69
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: ERLIN1; Polyclonal Antibody; ID (ERLIN1; C10orf69; KE04; KEO4; SPFH1; Erlin-1; Endoplasmic reticulum lipid raft-associated protein 1; Protein KE04; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1) (MaxLight 490); Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1; anti-ERLIN1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human ERLIN1.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

• Applicable Applications for anti-ERLIN1 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within aa245-275 of human ERLIN1(NP_001094096.1; O75477).
• Conjugate: MaxLight490
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in HepG2,A549 cell line lysates (35ug/lane) usingMBS641788. This demonstrates MBS641788 detected the ERLIN1 protein (arrow).)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue using MBS641788 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS641788 for immunohistochemistry.)

Related Product Information for anti-ERLIN1 antibody

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs).

Product Categories/Family for anti-ERLIN1 antibody

Antibodies; KIAA; orf

References

1. Rose, J.E., et al. Mol. Med. 16(7-8):247-253 (2010), 2. Martins-de-Souza, D., et al. J Psychiatr Res (2010). In press, 3. Wang, Y., et al. Biochim. Biophys. Acta 1793(11):1710-1718(2009), 4. Pearce, M.M., et al. J. Biol. Chem. 84(16):10433-10445(2009), 5. Yuan, X., et al. Am. J. Hum. Genet. 83(4):520-528(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 154800489
• NCBI GeneID: 10613
• NCBI Accession #: NP_001094096.1
• NCBI GenBank Nucleotide #: NM_001100626.1
• UniProt Accession #: O75477; Q53HV0; B0QZ42
• Molecular Weight: Predicted MW: 39kDa
• NCBI Official Full Name: erlin-1 isoform a
• NCBI Official Synonym Full Names: ER lipid raft associated 1
• NCBI Official Symbol: ERLIN1
• NCBI Official Synonym Symbols: KE04; KEO4; SPFH1; SPG62; Erlin-1; C10orf69
• NCBI Protein Information: erlin-1
• UniProt Protein Name: Erlin-1
• Protein Family: Erlin
• UniProt Gene Name: ERLIN1
• UniProt Synonym Gene Names: C10orf69; KE04; KEO4; SPFH1; SPFH domain-containing protein 1
• UniProt Entry Name: ERLN1_HUMAN

NCBI Description

The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62. [provided by RefSeq, Dec 2016]