Rabbit anti-Human EphA4 Receptor Polyclonal Antibody | anti-Epha4 antibody

EphA4 Receptor (Ephrin A4 Receptor)

Cat. Num. AAA610928

• Gene Names: Epha4; rb; Sek; Cek8; Hek8; Sek1; Tyro1; AI385584; 2900005C20Rik
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: EphA4 Receptor; Polyclonal Antibody; EphA4 Receptor (Ephrin A4 Receptor); Anti -EphA4 Receptor (Ephrin A4 Receptor); anti-Epha4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes Human Ephrin Type A Receptor 4 (EPHA4). Species Crossreactivity: Human.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.1% sodium azide.

• Applicable Applications for anti-Epha4 antibody: Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry.; Dilution: Immunohistochemistry: 18ug/ml
• Immunogen: Synthetic peptide, KLH-conjugated. Epitope: C-terminal domain of human
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Immunohistochemistry (IHC)

(Human Glomerulus (formalin-fixed, paraffin-embedded) stained with EPHA4 antibody at 18 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.)

Product Categories/Family for anti-Epha4 antibody

Antibodies; Abs to Receptors; Tyrosine Kinase

NCBI and Uniprot Product Information

• NCBI GI #: 34328113
• NCBI GeneID: 13838
• NCBI Accession #: NP_031962.2
• NCBI GenBank Nucleotide #: NM_007936.3
• UniProt Accession #: Q03137; Q80VZ2
• Molecular Weight: 109,814 Da
• NCBI Official Full Name: ephrin type-A receptor 4
• NCBI Official Synonym Full Names: Eph receptor A4
• NCBI Official Symbol: Epha4
• NCBI Official Synonym Symbols: rb; Sek; Cek8; Hek8; Sek1; Tyro1; AI385584; 2900005C20Rik
• NCBI Protein Information: ephrin type-A receptor 4; tyrosine-protein kinase receptor MPK-3; tyrosine-protein kinase receptor SEK-1
• UniProt Protein Name: Ephrin type-A receptor 4
• Protein Family: Ephrin type-A receptor
• UniProt Gene Name: Epha4
• UniProt Synonym Gene Names: Sek; Sek1
• UniProt Entry Name: EPHA4_MOUSE

Uniprot Description

EphA4: a tyrosine kinase receptor of the Eph family. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in hindbrain pattern formation. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels.

Protein type: Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (receptor); Membrane protein, integral; EC 2.7.10.1; TK group; Eph family

Cellular Component: Golgi apparatus; cell surface; integral to plasma membrane; endoplasmic reticulum; postsynaptic density; dendrite; dendritic spine; integral to membrane; perikaryon; postsynaptic membrane; mitochondrial outer membrane; cell projection; membrane; axon; early endosome membrane; cytoplasm; plasma membrane; synapse; nerve terminal; cell junction; neuromuscular junction; endosome; filopodium

Molecular Function: identical protein binding; ephrin receptor binding; transmembrane-ephrin receptor activity; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; protein kinase activity; transferase activity; protein binding; GPI-linked ephrin receptor activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; ephrin receptor activity; kinase activity; PH domain binding; ATP binding

Biological Process: axon guidance; nervous system development; positive regulation of JNK activity; regulation of GTPase activity; peptidyl-tyrosine phosphorylation; negative regulation of axon regeneration; multicellular organismal development; protein amino acid autophosphorylation; motor axon guidance; regulation of astrocyte differentiation; positive regulation of dendrite morphogenesis; regulation of axonogenesis; glial cell migration; adult walking behavior; protein amino acid phosphorylation; ephrin receptor signaling pathway; cell adhesion; corticospinal tract morphogenesis; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway