Western Blot (WB)
(Mouse Epha4 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Epha4 antibody detected the Epha4 protein (arrow).)
Rabbit anti-Human, mouse Epha4 Polyclonal Antibody | anti-Epha4 antibody
Mouse Epha4 Antibody (Center)
Western Blot (WB)
(Mouse Epha4 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Epha4 antibody detected the Epha4 protein (arrow).)
Western Blot (WB)
(Mouse Epha4 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Epha4 antibody detected the Epha4 protein (arrow).)
Immunohistochemistry (IHC)
(Mouse Epha4 Antibody (Center) (MBS9211801)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Epha4 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Mouse Epha4 Antibody (Center) (MBS9211801)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Epha4 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Qu, Y., et al. J. Neurosci. 30(28):9392-9401(2010)
Oginuma, M., et al. Development 137(9):1515-1522(2010)
Xie, Z., et al. Proc. Natl. Acad. Sci. U.S.A. 107(14):6510-6515(2010)
Galimberti, I., et al. Neuron 65(5):627-642(2010)
NCBI and Uniprot Product Information
Uniprot Description
EphA4: a tyrosine kinase receptor of the Eph family. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in hindbrain pattern formation. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels.
Protein type: Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; TK group; Eph family
Cellular Component: Golgi apparatus; cell surface; endoplasmic reticulum; integral to plasma membrane; postsynaptic density; dendrite; integral to membrane; dendritic spine; perikaryon; postsynaptic membrane; mitochondrial outer membrane; cell projection; membrane; early endosome membrane; axon; cytoplasm; plasma membrane; synapse; nerve terminal; cell junction; neuromuscular junction; endosome; filopodium
Molecular Function: identical protein binding; ephrin receptor binding; transmembrane-ephrin receptor activity; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; protein kinase activity; transferase activity; protein binding; GPI-linked ephrin receptor activity; protein-tyrosine kinase activity; ephrin receptor activity; transferase activity, transferring phosphorus-containing groups; kinase activity; PH domain binding; ATP binding
Biological Process: positive regulation of JNK activity; axon guidance; nervous system development; regulation of GTPase activity; peptidyl-tyrosine phosphorylation; negative regulation of axon regeneration; protein amino acid autophosphorylation; multicellular organismal development; regulation of astrocyte differentiation; motor axon guidance; positive regulation of dendrite morphogenesis; regulation of axonogenesis; glial cell migration; adult walking behavior; protein amino acid phosphorylation; ephrin receptor signaling pathway; cell adhesion; corticospinal tract morphogenesis; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on Epha4
Similar Products
Product Notes
The Epha4 epha4 (Catalog #AAA9211801) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 464-492. The Mouse Epha4 Antibody (Center) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Epha4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the Epha4 epha4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Epha4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
