Western Blot (WB)
(Lanes:1. 50 ug xenopus laevis embryos lysate (lysate buffer) 2. 50 ug xenopus laevis embryos lysate (HB buffer)Primary Antibody Dilution:1:300Secondary Antibody:Goat Anti-Rabbit APSecondary Antibody Dilution:1:20,000Gene Name:EPB41Submitted by:Rosa Carotenuto, Department of Structural and Functional Biology, University of Naples 'Federico II')
Rabbit EPB41 Polyclonal Antibody | anti-EPB41 antibody
EPB41 antibody - N-terminal region
Western Blot (WB)
(Lanes:1. 50 ug xenopus laevis embryos lysate (lysate buffer) 2. 50 ug xenopus laevis embryos lysate (HB buffer)Primary Antibody Dilution:1:300Secondary Antibody:Goat Anti-Rabbit APSecondary Antibody Dilution:1:20,000Gene Name:EPB41Submitted by:Rosa Carotenuto, Department of Structural and Functional Biology, University of Naples 'Federico II')
Western Blot (WB)
(Lanes:1. 50 ug xenopus laevis embryos lysate (lysate buffer) 2. 50 ug xenopus laevis embryos lysate (HB buffer)Primary Antibody Dilution:1:300Secondary Antibody:Goat Anti-Rabbit APSecondary Antibody Dilution:1:20,000Gene Name:EPB41Submitted by:Rosa Carotenuto, Department of Structural and Functional Biology, University of Naples 'Federico II')
Western Blot (WB)
(WB Suggested Anti-EPB41 Antibody Titration: 0.2-1 ug/mlPositive Control: Human Spleen)
Western Blot (WB)
(WB Suggested Anti-EPB41 Antibody Titration: 0.2-1 ug/mlPositive Control: Human Spleen)
Target Description: Elliptocytosis is a hematologic disorder characterized by elliptically shaped erythrocytes and a variable degree of hemolytic anemia. Inherited as an autosomal dominant, elliptocytosis results from mutation in any one of several genes encoding proteins of
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]
Uniprot Description
EPB41: Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Defects in EPB41 are the cause of elliptocytosis type 1 (EL1). EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP). HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 1p33-p32
Cellular Component: spectrin; cortical cytoskeleton; Golgi apparatus; protein complex; extrinsic to membrane; intracellular membrane-bound organelle; plasma membrane; nucleus
Molecular Function: calmodulin binding; protein binding; spectrin binding; structural constituent of cytoskeleton; actin binding; phosphatidylinositol binding
Biological Process: positive regulation of protein binding; blood circulation; cortical actin cytoskeleton organization and biogenesis; actin cytoskeleton organization and biogenesis
Disease: Elliptocytosis 1; Pyropoikilocytosis, Hereditary
Research Articles on EPB41
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Product Notes
The EPB41 epb41 (Catalog #AAA3206536) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The EPB41 antibody - N-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's EPB41 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the EPB41 epb41 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: EKGEGGQKEI EFGTSLDEEI ILKAPIAAPE PELKTDPSLD LHSLSSAETQ. It is sometimes possible for the material contained within the vial of "EPB41, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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