Goat EnvR / ERV3 Polyclonal Antibody | anti-ERV3-1 antibody

Goat Polyclonal to Human EnvR / ERV3

Cat. Num. AAA243448

• Gene Names: ERV3-1; ERV3; ERVR; envR; ERV-R; HERVR; HERV-R
• Reactivity: Chimpanzee, Human, Orangutan; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: EnvR / ERV3; Polyclonal Antibody; Goat Polyclonal to Human EnvR / ERV3; Anti-EnvR / ERV3 Antibody (Internal) IHC-plus; EnvR; ERV-3 envelope protein; ERV-R envelope protein; ERV3 envelope protein; HERVR; H-plk; Envelope polyprotein; ERV-R; ERV3-1 envelope protein; HERV-R; HERV-R envelope protein; Human EnvR; ERV3; anti-ERV3-1 antibody

• Host: Goat
• Reactivity: Chimpanzee, Human, Orangutan; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human ERV3.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 604

• Applicable Applications for anti-ERV3-1 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:4000), IHC-P (3.75 ug/ml); Usage: Peptide ELISA: antibody detection limit dilution 1:4000. Western blot: Preliminary experiments gave an approx 30kD band in Human Placenta lysates after 1 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literat...
• Target Species: Human
• Immunogen Description: Synthetic peptide C-PQDNFTLTASS from an internal region of human ERV3 (NP_001007254.2). Percent identity by BLAST analysis: Human, Chimpanzee, Orangutan (100%); Monkey (91%).
• Immunogen Type: Synthetic peptide
• Immunogen: EnvR / ERV3 antibody was raised against synthetic peptide C-PQDNFTLTASS from an internal region of human ERV3 (NP_001007254.2). Percent identity by BLAST analysis: Human, Chimpanzee, Orangutan (100%); Monkey (91%).
• Antigen Modification: Internal
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-ERV3 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 145651814
• NCBI GeneID: 2086
• NCBI Accession #: NP_001007254.2
• NCBI GenBank Nucleotide #: NM_001007253.3
• UniProt Accession #: Q14264
• Molecular Weight: 67,942 Da
• NCBI Official Full Name: endogenous retrovirus group 3 member 1 Env polyprotein
• NCBI Official Synonym Full Names: endogenous retrovirus group 3, member 1
• NCBI Official Symbol: ERV3-1
• NCBI Official Synonym Symbols: ERV3; ERVR; envR; ERV-R; HERVR; HERV-R
• NCBI Protein Information: endogenous retrovirus group 3 member 1 Env polyprotein; ERV-3 envelope protein; ERV-R envelope protein; ERV3-1 envelope protein; HERV-R envelope protein; endogenous retroviral sequence 3; HERV-R_7q21.2 provirus ancestral Env polyprotein
• UniProt Protein Name: Endogenous retrovirus group 3 member 1 Env polyprotein
• Protein Family: Endogenous retrovirus group 3 member 1 Env polyprotein
• UniProt Gene Name: ERV3-1
• UniProt Synonym Gene Names: ERV3; ERV3 envelope protein; ERV-R envelope protein; SU; TM
• UniProt Entry Name: ENR1_HUMAN

NCBI Description

The human genome includes many retroelements including the human endogenous retroviruses (HERVs). ERV3, one of the most studied HERVs, is thought to have integrated 30 to 40 million years ago and is present in higher primates with the exception of gorillas. Taken together, the observation of genome conservation, the detection of transcript expression, and the presence of conserved ORFs is circumstantial evidence for a functional role. A functional role is also suggested by the observation that downregulation of ERV3 is reported in choriocarcinoma. [provided by RefSeq, Jul 2008]

Uniprot Description

ERV3: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro. Belongs to the gamma type-C retroviral envelope protein family. HERV class-I R env subfamily.

Chromosomal Location of Human Ortholog: 7q11.2

Cellular Component: viral envelope